ASIC3 and Muscle Pain Export

@incollection{citeulike:3857649, abstract = {Highly sensitive acid-sensing ion channel 3 (ASIC3) is predominantly distributed in sensory neurons. Moderate acidification (pH 6.7–7.3) can open ASIC3 with sustained inward current, which is suitable for persistent pain sensation evoked by acidosis in arthritis, muscular ischemia, and cancer, for example. Mice with null mutation of ASIC3 show enhanced responses to cutaneous pain stimuli, including heat, pressure, and acetic acid. Also, the hyperalgesia induced by intradermal inflammation is not changed or augmented. This evidence argues against ASIC3 triggering cutaneous pain. In contrast, muscle pain associated with acidosis requires ASIC3 for the development of chronic mechanical hyperalgesia. Therefore, ASIC3 in muscle afferents seems to act as a peripheral initiator of muscle pain associated with acidosis.}, author = {Chen, Chih-Cheng}, citeulike-article-id = {3857649}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/978-4-431-73464-2_13}, citeulike-linkout-1 = {http://www.springerlink.com/content/u0110281016n7203}, doi = {10.1007/978-4-431-73464-2_13}, journal = {Novel Trends in Brain Science}, keywords = {asic3, muscle\_, pain}, pages = {225--232}, posted-at = {2009-01-07 16:22:06}, priority = {3}, title = {ASIC3 and Muscle Pain}, url = {http://dx.doi.org/10.1007/978-4-431-73464-2_13}, year = {2008} }

TY - CHAP ID - citeulike:3857649 L3 - citeulike-article-id:3857649 N2 - Highly sensitive acid-sensing ion channel 3 (ASIC3) is predominantly distributed in sensory neurons. Moderate acidification (pH 6.7–7.3) can open ASIC3 with sustained inward current, which is suitable for persistent pain sensation evoked by acidosis in arthritis, muscular ischemia, and cancer, for example. Mice with null mutation of ASIC3 show enhanced responses to cutaneous pain stimuli, including heat, pressure, and acetic acid. Also, the hyperalgesia induced by intradermal inflammation is not changed or augmented. This evidence argues against ASIC3 triggering cutaneous pain. In contrast, muscle pain associated with acidosis requires ASIC3 for the development of chronic mechanical hyperalgesia. Therefore, ASIC3 in muscle afferents seems to act as a peripheral initiator of muscle pain associated with acidosis. JF - Novel Trends in Brain Science EP - 232 TI - ASIC3 and Muscle Pain SP - 225 KW - asic3 KW - muscle_ KW - pain AU - Chen, Chih-Cheng PY - 2008/// UR - http://dx.doi.org/10.1007/978-4-431-73464-2_13 ER -