TRPV1 is activated by both acidic and basic pH. Export

@article{citeulike:3873663, abstract = {Maintaining physiological pH is required for survival, and exposure to alkaline chemicals such as ammonia (smelling salts) elicits severe pain and inflammation through unknown mechanisms. TRPV1, the capsaicin receptor, is an integrator of noxious stimuli including heat and extracellular acidic pH. Here, we report that ammonia activates TRPV1, TRPA1 (another polymodal nocisensor), and other unknown receptor(s) expressed in sensory neurons. Ammonia and intracellular alkalization activate TRPV1 through a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such as heat, capsaicin or low pH. Our studies show that TRPV1 detects both acidic and basic deviations from homeostatic pH.}, author = {Dhaka, A. and Uzzell, V. and Dubin, A. E. and Mathur, J. and Petrus, M. and Bandell, M. and Patapoutian, A.}, citeulike-article-id = {3873663}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.4901-08.2009}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/29/1/153}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19129393}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19129393}, day = {7}, doi = {10.1523/JNEUROSCI.4901-08.2009}, issn = {1529-2401}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, keywords = {acidity, basic, trpv1}, month = {January}, number = {1}, pages = {153--158}, posted-at = {2009-01-11 00:24:03}, priority = {3}, title = {TRPV1 is activated by both acidic and basic pH.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.4901-08.2009}, volume = {29}, year = {2009} }

TY - JOUR ID - citeulike:3873663 L3 - citeulike-article-id:3873663 N2 - Maintaining physiological pH is required for survival, and exposure to alkaline chemicals such as ammonia (smelling salts) elicits severe pain and inflammation through unknown mechanisms. TRPV1, the capsaicin receptor, is an integrator of noxious stimuli including heat and extracellular acidic pH. Here, we report that ammonia activates TRPV1, TRPA1 (another polymodal nocisensor), and other unknown receptor(s) expressed in sensory neurons. Ammonia and intracellular alkalization activate TRPV1 through a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such as heat, capsaicin or low pH. Our studies show that TRPV1 detects both acidic and basic deviations from homeostatic pH. IS - 1 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience SN - 1529-2401 EP - 158 TI - TRPV1 is activated by both acidic and basic pH. VL - 29 SP - 153 KW - acidity KW - basic KW - trpv1 AU - Dhaka, A AU - Uzzell, V AU - Dubin, AE AU - Mathur, J AU - Petrus, M AU - Bandell, M AU - Patapoutian, A PY - 2009/01/07/ UR - http://dx.doi.org/10.1523/JNEUROSCI.4901-08.2009 ER -