Neuroendocrine abnormalities in fibromyalgia Export

@article{citeulike:3885357, abstract = {Abstract\ \ Fibromyalgia is a disorder of unknown etiology characterized by chronic, widespread musculoskeletal pain and symptoms such as fatigue, poor sleep, gastrointestinal complaints, and psychologic problems that are similar to those experienced by patients with hormone deficiencies. This review summarizes the available data on the neuroendocrine function in fibromyalgia, including data on hormone secretion, circadian phase, and autonomic nervous system function. Studies suggest that there may be lower activity of a number of hypothalamic-pituitaryperipheral gland axes and altered autonomic nervous system function in patients with fibromyalgia. These reductions in activity are mild to moderate and do not result from alterations in circadian rhythms. The reduced hormonal and autonomic responses appear to reflect an impairment in the hypothalamic or central nervous system response to stimuli rather than a primary defect at the level of the pituitary gland or the peripheral glands. A combination of multiple, mild impaired responses may lead to more profound physiologic and clinical consequences as compared with a defect in only one system, and could contribute to the symptoms of fibromyalgia.}, author = {Adler, Gail and Manfredsdottir, Valdis and Creskoff, Katharine}, citeulike-article-id = {3885357}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s11916-002-0050-5}, citeulike-linkout-1 = {http://www.springerlink.com/content/n2w1822r677786t5}, day = {1}, doi = {10.1007/s11916-002-0050-5}, journal = {Current Pain and Headache Reports}, keywords = {cns, fibromyalgia, hpa, neuroendocrine\_abnormalities}, number = {4}, pages = {289--298}, posted-at = {2009-01-14 13:24:17}, priority = {2}, title = {Neuroendocrine abnormalities in fibromyalgia}, url = {http://dx.doi.org/10.1007/s11916-002-0050-5}, volume = {6}, year = {2002} }

TY - JOUR ID - citeulike:3885357 L3 - citeulike-article-id:3885357 N2 - Abstract  Fibromyalgia is a disorder of unknown etiology characterized by chronic, widespread musculoskeletal pain and symptoms such as fatigue, poor sleep, gastrointestinal complaints, and psychologic problems that are similar to those experienced by patients with hormone deficiencies. This review summarizes the available data on the neuroendocrine function in fibromyalgia, including data on hormone secretion, circadian phase, and autonomic nervous system function. Studies suggest that there may be lower activity of a number of hypothalamic-pituitaryperipheral gland axes and altered autonomic nervous system function in patients with fibromyalgia. These reductions in activity are mild to moderate and do not result from alterations in circadian rhythms. The reduced hormonal and autonomic responses appear to reflect an impairment in the hypothalamic or central nervous system response to stimuli rather than a primary defect at the level of the pituitary gland or the peripheral glands. A combination of multiple, mild impaired responses may lead to more profound physiologic and clinical consequences as compared with a defect in only one system, and could contribute to the symptoms of fibromyalgia. IS - 4 JF - Current Pain and Headache Reports EP - 298 TI - Neuroendocrine abnormalities in fibromyalgia VL - 6 SP - 289 KW - cns KW - fibromyalgia KW - hpa KW - neuroendocrine_abnormalities AU - Adler, Gail AU - Manfredsdottir, Valdis AU - Creskoff, Katharine PY - 2002//01/ UR - http://dx.doi.org/10.1007/s11916-002-0050-5 ER -