The Heme Oxygenase-1/Carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-1 Export

@article{citeulike:4268076, abstract = {Caveolin-1 (cav-1), the principle structural protein of plasmalemmal caveolae, regulates inflammatory signaling processes originating at the membrane. We show that cav-1 bound to TLR4 and inhibited LPS-induced proinflammatory cytokine (TNF-{alpha} and IL-6) production in murine macrophages. Mutation analysis revealed a cav-1 binding motif in TLR4, essential for this interaction and for attenuation of proinflammatory signaling. Cav-1 was required for the anti-inflammatory effects of carbon monoxide (CO), a product of heme oxygenase-1 (HO-1) activity. CO augmented the cav-1/TLR4 interaction. Upon LPS stimulation, HO-1 trafficked to the caveolae by a p38 MAPK-dependent mechanism, where it down-regulated proinflammatory signaling. These results reveal an anti-inflammatory network involving cav-1 and HO-1. 10.4049/jimmunol.0712437}, author = {Wang, Xiao M. and Kim, Hong P. and Nakahira, Kiichi and Ryter, Stefan W. and Choi, Augustine M. K.}, citeulike-article-id = {4268076}, citeulike-linkout-0 = {http://dx.doi.org/10.4049/jimmunol.0712437}, citeulike-linkout-1 = {http://www.jimmunol.org/content/182/6/3809.abstract}, citeulike-linkout-2 = {http://www.jimmunol.org/content/182/6/3809.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19265160}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19265160}, day = {15}, doi = {10.4049/jimmunol.0712437}, issn = {1550-6606}, journal = {J Immunol}, month = {March}, number = {6}, pages = {3809--3818}, posted-at = {2009-10-27 00:56:00}, priority = {3}, title = {The Heme Oxygenase-1/Carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-1}, url = {http://dx.doi.org/10.4049/jimmunol.0712437}, volume = {182}, year = {2009} }

TY - JOUR ID - citeulike:4268076 L3 - citeulike-article-id:4268076 N2 - Caveolin-1 (cav-1), the principle structural protein of plasmalemmal caveolae, regulates inflammatory signaling processes originating at the membrane. We show that cav-1 bound to TLR4 and inhibited LPS-induced proinflammatory cytokine (TNF-{alpha} and IL-6) production in murine macrophages. Mutation analysis revealed a cav-1 binding motif in TLR4, essential for this interaction and for attenuation of proinflammatory signaling. Cav-1 was required for the anti-inflammatory effects of carbon monoxide (CO), a product of heme oxygenase-1 (HO-1) activity. CO augmented the cav-1/TLR4 interaction. Upon LPS stimulation, HO-1 trafficked to the caveolae by a p38 MAPK-dependent mechanism, where it down-regulated proinflammatory signaling. These results reveal an anti-inflammatory network involving cav-1 and HO-1. 10.4049/jimmunol.0712437 IS - 6 JF - J Immunol SN - 1550-6606 EP - 3818 TI - The Heme Oxygenase-1/Carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-1 VL - 182 SP - 3809 AU - Wang, Xiao AU - Kim, Hong AU - Nakahira, Kiichi AU - Ryter, Stefan AU - Choi, Augustine PY - 2009/03/15/ UR - http://dx.doi.org/10.4049/jimmunol.0712437 ER -