Plasma IL-6, its soluble receptors and F-isoprostanes at rest and during exercise in chronic fatigue syndrome. Export

@article{citeulike:4505828, abstract = {The aim of the current study was to investigate the levels of interleukin-6 (IL-6), its soluble receptors (sIL-6R and sgp130) and F(2)-isoprostanes, at rest and during exercise, in patients with chronic fatigue syndrome (CFS). Six male CFS patients and six healthy controls performed an incremental exercise test to exhaustion and a submaximal exercise bout to exhaustion. Blood samples taken in the submaximal test at rest, immediately post-exercise and 24 h post-exercise were analyzed for IL-6, sIL-6R, sgp130 and F(2)-isoprostanes. A further 33 CFS and 33 healthy control participants gave a resting blood sample for IL-6 and sIL-6R measurement. During the incremental exercise test only power output at the lactate threshold was lower (P<0.05) in the CFS group. F(2)-isoprostanes were higher (P<0.05) in CFS patients at rest and this difference persisted immediately and 24 h post-exercise. The exercise study found no differences in IL-6, sIL-6R or sgp130 at any time point between groups. In the larger resting group, there were no differences in IL-6 and sIL-6R between CFS and control groups. This investigation has demonstrated that patients with CFS do not have altered plasma levels of IL-6, sIL-6R or sgp130 either at rest or following exercise. F(2)-isoprostanes, however, were consistently higher in CFS patients.}, author = {Robinson, M and Gray, S R R. and Watson, M S S. and Kennedy, G and Hill, A and Belch, J J F J. and Nimmo, M A A.}, citeulike-article-id = {4505828}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1600-0838.2009.00895.x}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19422646}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19422646}, day = {13}, doi = {10.1111/j.1600-0838.2009.00895.x}, issn = {1600-0838}, journal = {Scandinavian journal of medicine \& science in sports}, keywords = {cfs, il-6, isoprostanes}, month = {April}, posted-at = {2009-05-12 19:29:55}, priority = {3}, title = {Plasma IL-6, its soluble receptors and F-isoprostanes at rest and during exercise in chronic fatigue syndrome.}, url = {http://dx.doi.org/10.1111/j.1600-0838.2009.00895.x}, year = {2009} }

TY - JOUR ID - citeulike:4505828 L3 - citeulike-article-id:4505828 N2 - The aim of the current study was to investigate the levels of interleukin-6 (IL-6), its soluble receptors (sIL-6R and sgp130) and F(2)-isoprostanes, at rest and during exercise, in patients with chronic fatigue syndrome (CFS). Six male CFS patients and six healthy controls performed an incremental exercise test to exhaustion and a submaximal exercise bout to exhaustion. Blood samples taken in the submaximal test at rest, immediately post-exercise and 24 h post-exercise were analyzed for IL-6, sIL-6R, sgp130 and F(2)-isoprostanes. A further 33 CFS and 33 healthy control participants gave a resting blood sample for IL-6 and sIL-6R measurement. During the incremental exercise test only power output at the lactate threshold was lower (P<0.05) in the CFS group. F(2)-isoprostanes were higher (P<0.05) in CFS patients at rest and this difference persisted immediately and 24 h post-exercise. The exercise study found no differences in IL-6, sIL-6R or sgp130 at any time point between groups. In the larger resting group, there were no differences in IL-6 and sIL-6R between CFS and control groups. This investigation has demonstrated that patients with CFS do not have altered plasma levels of IL-6, sIL-6R or sgp130 either at rest or following exercise. F(2)-isoprostanes, however, were consistently higher in CFS patients. JF - Scandinavian journal of medicine & science in sports SN - 1600-0838 TI - Plasma IL-6, its soluble receptors and F-isoprostanes at rest and during exercise in chronic fatigue syndrome. KW - cfs KW - il-6 KW - isoprostanes AU - Robinson, M AU - Gray, S R AU - Watson, M S AU - Kennedy, G AU - Hill, A AU - Belch, J J F AU - Nimmo, M A PY - 2009/04/13/ UR - http://dx.doi.org/10.1111/j.1600-0838.2009.00895.x ER -