Angiotensin II Increases Leptin Secretion by 3T3-L1 and Human Adipocytes via a Prostaglandin-Independent Mechanism Export

@article{citeulike:4635135, abstract = {We previously reported that angiotensin II (Ang II) increases adipocyte fatty acid synthesis and triglyceride content. Triglyceride stores or adiposity correlate positively with the amount of circulating leptin. Ang II was proposed to increase adipocyte differentiation and growth by promoting prostaglandin (PG) production. The purpose of this study was to determine whether Ang II increases leptin secretion via a PG-dependent mechanism. Physiologic doses of Ang II significantly increased leptin secretion by 3T3-L1 adipocytes and human adipocytes. Elevation of PG secretions was elicited at physiologic concentrations of Ang II (P < 0.05). Secretions of 6-keto PGF1{alpha}, a stable derivative of PGI2, and PGE2 were induced by physiologic concentrations of Ang II in a time-responsive fashion (P < 0.05). Inhibition of PG synthesis by indomethacin and aspirin significantly suppressed basal as well as Ang II-induced PG levels, but did not significantly affect basal and Ang II-induced leptin secretion. In conclusion, although Ang II stimulates both leptin and PG secretion by adipocytes, regulation of leptin secretion by Ang II in adipocytes is not mediated by a PG-dependent mechanism.}, author = {Kim, Suyeon and Whelan, Jay and Claycombe, Kate and Reath, David B. and Moustaid-Moussa, Naima}, citeulike-article-id = {4635135}, citeulike-linkout-0 = {http://jn.nutrition.org/cgi/content/abstract/132/6/1135}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12042422}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12042422}, day = {1}, journal = {J. Nutr.}, keywords = {adipocytes, angiotensin, leptin}, month = {June}, number = {6}, pages = {1135--1140}, posted-at = {2009-05-26 11:43:56}, priority = {3}, title = {Angiotensin II Increases Leptin Secretion by 3T3-L1 and Human Adipocytes via a Prostaglandin-Independent Mechanism}, url = {http://jn.nutrition.org/cgi/content/abstract/132/6/1135}, volume = {132}, year = {2002} }

TY - JOUR ID - citeulike:4635135 L3 - citeulike-article-id:4635135 N2 - We previously reported that angiotensin II (Ang II) increases adipocyte fatty acid synthesis and triglyceride content. Triglyceride stores or adiposity correlate positively with the amount of circulating leptin. Ang II was proposed to increase adipocyte differentiation and growth by promoting prostaglandin (PG) production. The purpose of this study was to determine whether Ang II increases leptin secretion via a PG-dependent mechanism. Physiologic doses of Ang II significantly increased leptin secretion by 3T3-L1 adipocytes and human adipocytes. Elevation of PG secretions was elicited at physiologic concentrations of Ang II (P < 0.05). Secretions of 6-keto PGF1{alpha}, a stable derivative of PGI2, and PGE2 were induced by physiologic concentrations of Ang II in a time-responsive fashion (P < 0.05). Inhibition of PG synthesis by indomethacin and aspirin significantly suppressed basal as well as Ang II-induced PG levels, but did not significantly affect basal and Ang II-induced leptin secretion. In conclusion, although Ang II stimulates both leptin and PG secretion by adipocytes, regulation of leptin secretion by Ang II in adipocytes is not mediated by a PG-dependent mechanism. IS - 6 JF - J. Nutr. EP - 1140 TI - Angiotensin II Increases Leptin Secretion by 3T3-L1 and Human Adipocytes via a Prostaglandin-Independent Mechanism VL - 132 SP - 1135 KW - adipocytes KW - angiotensin KW - leptin AU - Kim, Suyeon AU - Whelan, Jay AU - Claycombe, Kate AU - Reath, David AU - Moustaid-Moussa, Naima PY - 2002/06/01/ UR - http://jn.nutrition.org/cgi/content/abstract/132/6/1135 ER -