Successful generation of peripheral neuropathy with onion-bulb formation in the macrophage scavenger receptor classA knockout mouse treated with isoniazid. Export

@article{citeulike:5047949, abstract = {We previously reported successful generation of many onion-bulbs (OBs) and formation of oxidized phosphatidylcholine after compression injury to the peripheral nerve of mice deficient of macrophage scavenger receptor classA (MSR-A). In the present study, we employed chemical injury with isoniazid to the peripheral nerve of the MSR-A knockout mice to investigate the role of the MSR-A in toxic neuropathy. Peripheral neuropathy has not previously been generated with isoniazid in mice. In the present study, we also noted little histological change after isoniazid administration not only to control littermates but also to the A/J strain mice known to be slow acetylators. Surprisingly, however, we were successful in generating peripheral neuropathy with isoniazid in the MSR-A knockout mice. Histologically, the predominant feature was the presence of many thinly myelinated fibers with some OBs, which have not been observed in rats with isoniazid neuropathy. Deficiency of the MSR-A appears to have played an important role in generation of peripheral neuropathy with isoniazid in mice.}, author = {Naba, I. and Yoshikawa, H. and Sakoda, S. and Itabe, H. and Suzuki, H. and Kodama, T. and Yanagihara, T.}, citeulike-article-id = {5047949}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10925161}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10925161}, day = {18}, issn = {0304-3940}, journal = {Neuroscience letters}, month = {August}, number = {1}, pages = {5--8}, posted-at = {2009-07-03 17:51:27}, priority = {3}, title = {Successful generation of peripheral neuropathy with onion-bulb formation in the macrophage scavenger receptor classA knockout mouse treated with isoniazid.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10925161}, volume = {290}, year = {2000} }

TY - JOUR ID - citeulike:5047949 L3 - citeulike-article-id:5047949 N2 - We previously reported successful generation of many onion-bulbs (OBs) and formation of oxidized phosphatidylcholine after compression injury to the peripheral nerve of mice deficient of macrophage scavenger receptor classA (MSR-A). In the present study, we employed chemical injury with isoniazid to the peripheral nerve of the MSR-A knockout mice to investigate the role of the MSR-A in toxic neuropathy. Peripheral neuropathy has not previously been generated with isoniazid in mice. In the present study, we also noted little histological change after isoniazid administration not only to control littermates but also to the A/J strain mice known to be slow acetylators. Surprisingly, however, we were successful in generating peripheral neuropathy with isoniazid in the MSR-A knockout mice. Histologically, the predominant feature was the presence of many thinly myelinated fibers with some OBs, which have not been observed in rats with isoniazid neuropathy. Deficiency of the MSR-A appears to have played an important role in generation of peripheral neuropathy with isoniazid in mice. IS - 1 JF - Neuroscience letters SN - 0304-3940 EP - 8 TI - Successful generation of peripheral neuropathy with onion-bulb formation in the macrophage scavenger receptor classA knockout mouse treated with isoniazid. VL - 290 SP - 5 AU - Naba, I AU - Yoshikawa, H AU - Sakoda, S AU - Itabe, H AU - Suzuki, H AU - Kodama, T AU - Yanagihara, T PY - 2000/08/18/ UR - http://view.ncbi.nlm.nih.gov/pubmed/10925161 ER -