Potential mechanisms of muscle mitochondrial dysfunction in aging and obesity and cellular consequences. Export

@article{citeulike:5095864, abstract = {Mitochondria play a key role in the energy metabolism in skeletal muscle. A new concept has emerged suggesting that impaired mitochondrial oxidative capacity in skeletal muscle may be the underlying defect that causes insulin resistance. According to current knowledge, the causes and the underlying molecular mechanisms at the origin of decreased mitochondrial oxidative capacity in skeletal muscle still remain to be elucidated. The present review focuses on recent data investigating these issues in the area of metabolic disorders and describes the potential causes, mechanisms and consequences of mitochondrial dysfunction in the skeletal muscle.}, author = {Chans\'{e}aume, Emilie and Morio, B\'{e}atrice}, citeulike-article-id = {5095864}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19333447}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19333447}, issn = {1422-0067}, journal = {International journal of molecular sciences}, keywords = {pgc-1a, tetrahydrobiopterin}, month = {January}, number = {1}, pages = {306--324}, posted-at = {2009-07-09 13:54:15}, priority = {3}, title = {Potential mechanisms of muscle mitochondrial dysfunction in aging and obesity and cellular consequences.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/19333447}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5095864 L3 - citeulike-article-id:5095864 N2 - Mitochondria play a key role in the energy metabolism in skeletal muscle. A new concept has emerged suggesting that impaired mitochondrial oxidative capacity in skeletal muscle may be the underlying defect that causes insulin resistance. According to current knowledge, the causes and the underlying molecular mechanisms at the origin of decreased mitochondrial oxidative capacity in skeletal muscle still remain to be elucidated. The present review focuses on recent data investigating these issues in the area of metabolic disorders and describes the potential causes, mechanisms and consequences of mitochondrial dysfunction in the skeletal muscle. IS - 1 JF - International journal of molecular sciences SN - 1422-0067 EP - 324 TI - Potential mechanisms of muscle mitochondrial dysfunction in aging and obesity and cellular consequences. VL - 10 SP - 306 KW - pgc-1a KW - tetrahydrobiopterin AU - Chanséaume, Emilie AU - Morio, Béatrice PY - 2009/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/19333447 ER -