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Neuro endocrinology letters, Vol. 30, No. 6. (30 December 2009)
Abstract
There is now evidence that major depression and myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) are accompanied by partially overlapping pathophysiological mechanisms, i.e. activation of various inflammatory and oxidative & nitrosative (IO&NS) pathways. The aim of the present study was to examine the urinary excretion of 8-hydroxy-deoxyguanosine (8-OhdG), a marker of oxidative damage to DNA, in depression; ME/CFS; and depression and ME/CFS. Toward this end, morning urine was sampled for the assays of 8-OHdG and creatinine, in 44 patients with ME/CFS; ...
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Neuro endocrinology letters, Vol. 30, No. 6. (30 December 2009)
Abstract
There is evidence that disorders in inflammatory and oxidative and nitrosative (IO&NS) pathways and a lowered antioxidant status are important pathophysiological mechanisms underpinning myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). Important precipitating and perpetuating factors for ME/CFS are (amongst others) bacterial and viral infections; bacterial translocation due to an increased gut permeability; and psychological stress. Recently, Jason et al (2006) reported that the mean age of patients with myalgic encephalomyelitis/chronic fatigue syndrome dying from heart failure, i.e. 58.7 years, is significantly ...
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Affective Disorders, Vol. 120, No. 1. (January 2010), pp. 231-234
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Neuro endocrinology letters, Vol. 30, No. 4. (11 October 2009)
Abstract
Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a medical illness characterized by disorders in inflammatory and oxidative and nitrosative (IO&NS) pathways.This paper examines the role of Coenzyme Q10 (CoQ10), a mitochondrial nutrient which acts as an essential cofactor for the production of ATP in mitochondria and which displays significant antioxidant activities.Plasma CoQ10 has been assayed in 58 patients with ME/CFS and in 22 normal controls; the relationships between CoQ10 and the severity of ME/CFS as measured by means of the ...
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Neuro Endocrinol Lett, Vol. 26, No. 5. (30 October 2005)
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Abstract
Background: Recently, it has been reported that serum interleukin-1β (IL-1β), but not soluble IL-2 receptor (sIL-2R), concentrations were significantly higher in patients with posttraumatic stress disorder (PTSD) than in normal volunteers, and that psychological stress in humans is associated with increased secretion of proinflammatory cytokines, such as IL-6. Methods: The aim of the present study was to examine the inflammatory response system in patients with PTSD through measurements of serum IL-6, sIL-6R, sgp130 (the IL-6 signal transducing protein), sIL-1R antagonist (sIL-1RA; ...
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Abstract
There is some evidence that, in humans and experimental animals, psychological stress may suppress or enhance immune functions, depending on the nature of the stressor and the immune variables under consideration. The possibility that psychological stress may affect the production of pro-inflammatory and immunoregulatory cytokines was investigated in 38 medical students, who had blood samplings a few weeks before and after as well as one day before an academic examination. Psychological stress significantly increased the stimulated production of tumour necrosis factor ...
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Cytokine, Vol. 10, No. 4. (April 1998), pp. 313-318
by Michael Maes, Cai Song, Aihua Lin, et al.Raf De Jongh, An Van Gastela, Gunter Kenis, Eugene Bosmans, Ingrid De Meester, Ina B. Neels, Paul Demedts, Aleksandar Janca, Simon Scharpé, Ronald S. Smith
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Abstract
There is now evidence that chronic fatigue syndrome (CFS) is accompanied by immune disorders and by increased oxidative stress. The present study has been designed in order to examine the serum concentrations of IgA and IgM to LPS of gram-negative enterobacteria, i.e. Hafnia alvei; Pseudomonas aeruginosa, Morganella morganii, Proteus mirabilis, Pseudomonas putida, Citrobacter koseri, and Klebsiella pneumoniae in CFS patients, patients with partial CFS and normal controls. We found that the prevalences and median values for serum IgA against the LPS ...
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Neuroendocrinology Letter, Vol. 29, No. 1. (2008), pp. 117-124
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Neuro endocrinology letters, Vol. 29, No. 6. (29 December 2008), pp. 902-910
Abstract
There is now evidence that an increased translocation of LPS from gram negative bacteria with subsequent gut-derived inflammation, i.e. induction of systemic inflammation and oxidative & nitrosative stress (IO&NS), is a new pathway in chronic fatigue syndrome (CFS). The present study examines the serum concentrations of IgA and IgM to ...
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Current Opinion in Psychiatry, Vol. 22, No. 1. (January 2009), pp. 75-83
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Biological Psychiatry, Vol. 45, No. 7. (1999), pp. 833-839
Abstract
Background: Recently, it has been reported that serum interleukin-1β (IL-1β), but not soluble IL-2 receptor (slL-2R), concentrations were significantly higher in patients with posttraumatic stress disorder (PTSD) than in normal volunteers, and that psychological stress in humans is associated with increased secretion of proinflammatory cytokines, such as IL-6. Methods: The aim of the present study was to examine the inflammatory response system in patients with PTSD through measurements of serum IL-6, sIL-6R, sgp130 (the IL-6 signal transducing protein), sIL-1R antagonist (slL-1RA; ...
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