Th17: the third member of the effector T cell trilogy. Export

@article{citeulike:2369804, abstract = {T helper responses have now grown to include three T cell subsets: Th1, Th2 and Th17. Th17 cells have recently emerged as a third independent T cell subset that may play an essential role in protection against certain extracellular pathogens. However, Th17 cells with specificity for self-antigens are highly pathogenic and lead to the development of inflammation and severe autoimmunity. A combination of TGF-beta plus IL-6 and the transcription factors STAT3 and RORgammat were recently described to be essential for initial differentiation of Th17 cells and IL-23 for the later stabilization of the Th17 cell subset. Here, we introduce another player IL-21 produced by Th17 themselves, which plays an important role in the amplification of Th17 cells. Thus, Th17 cells may undergo three distinct steps of development: differentiation, amplification and stabilization in which distinct cytokines play a role.}, address = {Center for Neurologic Diseases, Brigham \& Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.}, author = {Bettelli, E. and Korn, T. and Kuchroo, V. K.}, citeulike-article-id = {2369804}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.coi.2007.07.020}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17766098}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17766098}, doi = {10.1016/j.coi.2007.07.020}, issn = {0952-7915}, journal = {Curr Opin Immunol}, keywords = {review, th17}, month = {December}, number = {6}, pages = {652--657}, posted-at = {2008-07-20 14:38:08}, priority = {2}, title = {Th17: the third member of the effector T cell trilogy.}, url = {http://dx.doi.org/10.1016/j.coi.2007.07.020}, volume = {19}, year = {2007} }

TY - JOUR ID - citeulike:2369804 L3 - citeulike-article-id:2369804 N2 - T helper responses have now grown to include three T cell subsets: Th1, Th2 and Th17. Th17 cells have recently emerged as a third independent T cell subset that may play an essential role in protection against certain extracellular pathogens. However, Th17 cells with specificity for self-antigens are highly pathogenic and lead to the development of inflammation and severe autoimmunity. A combination of TGF-beta plus IL-6 and the transcription factors STAT3 and RORgammat were recently described to be essential for initial differentiation of Th17 cells and IL-23 for the later stabilization of the Th17 cell subset. Here, we introduce another player IL-21 produced by Th17 themselves, which plays an important role in the amplification of Th17 cells. Thus, Th17 cells may undergo three distinct steps of development: differentiation, amplification and stabilization in which distinct cytokines play a role. IS - 6 JF - Curr Opin Immunol SN - 0952-7915 AD - Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. EP - 657 TI - Th17: the third member of the effector T cell trilogy. VL - 19 SP - 652 KW - review KW - th17 AU - Bettelli, E AU - Korn, T AU - Kuchroo, VK PY - 2007/12// UR - http://dx.doi.org/10.1016/j.coi.2007.07.020 ER -