Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma. Export

@article{citeulike:2971428, abstract = {Background. @nbsp; Asthma, a serious health problem worldwide, is becoming more common. Colonization with Helicobacter pylori, a major human indigenous (commensal) microbe, during early life may be relevant to the risk of childhood asthma. Methods. @nbsp; We conducted cross-sectional analyses, using data from 7412 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2000, to assess the association between H. pylori and childhood asthma. Results. @nbsp; H. pylori seropositivity was inversely associated with onset of asthma before 5 years of age and current asthma in children aged 3-13 years. Among participants 3-19 years of age, the presence of H. pylori was inversely related to ever having had asthma (odds ratio [OR], 0.69; 95\% confidence interval [CI], 0.45-1.06), and the inverse association with onset of asthma before 5 years of age was stronger (OR, 0.58; 95\% CI, 0.38-0.88). Among participants 3-13 years of age, H. pylori positivity was significantly inversely associated with current asthma (OR, 0.41; 95\% CI, 0.24-0.69). H. pylori seropositivity also was inversely related to recent wheezing, allergic rhinitis, and dermatitis, eczema, or rash. Conclusions. @nbsp; This study is the first to report an inverse association between H. pylori seropositivity and asthma in children. The findings indicate new directions for research and asthma prevention.}, address = {Departments of 1Environmental Medicine, 3Medicine, and 4Microbiology, School of Medicine, and 2Cancer Institute, New York University, and 5Department of Veterans Affairs Medical Center, New York, New York.}, author = {Chen, Yu and Blaser, Martin J J.}, citeulike-article-id = {2971428}, citeulike-linkout-0 = {http://dx.doi.org/10.1086/590158}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18598192}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18598192}, day = {3}, doi = {10.1086/590158}, issn = {0022-1899}, journal = {The Journal of infectious diseases}, keywords = {asthma, cooperation, helicobacter\_pilory}, month = {July}, posted-at = {2008-08-14 16:12:30}, priority = {2}, title = {Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma.}, url = {http://dx.doi.org/10.1086/590158}, year = {2008} }

TY - JOUR ID - citeulike:2971428 L3 - citeulike-article-id:2971428 N2 - Background. @nbsp; Asthma, a serious health problem worldwide, is becoming more common. Colonization with Helicobacter pylori, a major human indigenous (commensal) microbe, during early life may be relevant to the risk of childhood asthma. Methods. @nbsp; We conducted cross-sectional analyses, using data from 7412 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2000, to assess the association between H. pylori and childhood asthma. Results. @nbsp; H. pylori seropositivity was inversely associated with onset of asthma before 5 years of age and current asthma in children aged 3-13 years. Among participants 3-19 years of age, the presence of H. pylori was inversely related to ever having had asthma (odds ratio [OR], 0.69; 95% confidence interval [CI], 0.45-1.06), and the inverse association with onset of asthma before 5 years of age was stronger (OR, 0.58; 95% CI, 0.38-0.88). Among participants 3-13 years of age, H. pylori positivity was significantly inversely associated with current asthma (OR, 0.41; 95% CI, 0.24-0.69). H. pylori seropositivity also was inversely related to recent wheezing, allergic rhinitis, and dermatitis, eczema, or rash. Conclusions. @nbsp; This study is the first to report an inverse association between H. pylori seropositivity and asthma in children. The findings indicate new directions for research and asthma prevention. JF - The Journal of infectious diseases SN - 0022-1899 AD - Departments of 1Environmental Medicine, 3Medicine, and 4Microbiology, School of Medicine, and 2Cancer Institute, New York University, and 5Department of Veterans Affairs Medical Center, New York, New York. TI - Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma. KW - asthma KW - cooperation KW - helicobacter_pilory AU - Chen, Yu AU - Blaser, Martin J PY - 2008/07/03/ UR - http://dx.doi.org/10.1086/590158 ER -