Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.

by: LC Ndhlovu, JM Chapman, AR Jha, JE Snyder-Cappione, M Pagán, FE Leal, BS Boland, PJ Norris, MG Rosenberg, DF Nixon

AIDS (London, England), Vol. 22, No. 8. (11 May 2008), pp. 990-992.

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Abstract

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

@article{citeulike:3015848, abstract = {IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.}, address = {Division of Experimental Medicine, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California 94110, USA. lishomwa.ndhlovu@ucsf.edu}, author = {Ndhlovu, L. C. and Chapman, J. M. and Jha, A. R. and Snyder-Cappione, J. E. and Pag\'{a}n, M. and Leal, F. E. and Boland, B. S. and Norris, P. J. and Rosenberg, M. G. and Nixon, D. F. }, citeulike-article-id = {3015848}, doi = {http://dx.doi.org/10.1097/QAD.0b013e3282ff884e}, issn = {1473-5571}, journal = {AIDS (London, England)}, keywords = {hiv-1, th17}, month = {May}, number = {8}, pages = {990--992}, posted-at = {2008-07-17 23:07:51}, priority = {2}, title = {Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.}, url = {http://dx.doi.org/10.1097/QAD.0b013e3282ff884e}, volume = {22}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:3015848 L3 - citeulike-article-id:3015848 TI - Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection. JF - AIDS (London, England) VL - 22 IS - 8 SP - 990 EP - 992 AD - Division of Experimental Medicine, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California 94110, USA. lishomwa.ndhlovu@ucsf.edu SN - 1473-5571 N2 - IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells. KW - hiv-1 KW - th17 AU - Ndhlovu, LC AU - Chapman, JM AU - Jha, AR AU - Snyder-Cappione, JE AU - Pagán, M AU - Leal, FE AU - Boland, BS AU - Norris, PJ AU - Rosenberg, MG AU - Nixon, DF PY - 2008/05/11/ UR - http://dx.doi.org/10.1097/QAD.0b013e3282ff884e ER -

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