CD4(+) T-cell subsets that mediate immunological memory to Mycobacterium tuberculosis infection in mice. Export

@article{citeulike:3044174, abstract = {We have studied CD4(+) T cells that mediate immunological memory to an intravenous infection with Mycobacterium tuberculosis. The studies were conducted with a mouse model of memory immunity in which mice are rendered immune by a primary infection followed by antibiotic treatment and rest. Shortly after reinfection, tuberculosis-specific memory cells were recruited from the recirculating pool, leading to rapidly increasing precursor frequencies in the liver and a simultaneous decrease in the blood. A small subset of the infiltrating T cells was rapidly activated (<20 h) and expressed high levels of intracellular gamma interferon and the T-cell activation markers CD69 and CD25. These memory effector T cells expressed intermediate levels of CD45RB and were heterogeneous with regard to the L-selectin and CD44 markers. By adoptive transfer into nude mice, the highest level of resistance to a challenge with M. tuberculosis was mediated by CD45RB(high), L-selectin(high), CD44(low) cells. Taken together, these two lines of evidence support an important role for memory cells which have reverted to a naive phenotype in the long-term protection against M. tuberculosis.}, address = {Department of TB Immunology, Statens Serum Institut, Copenhagen, Denmark. pa@ssi.dk}, author = {Andersen, P. and Smedegaard, B.}, citeulike-article-id = {3044174}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10639425}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10639425}, issn = {0019-9567}, journal = {Infection and immunity}, keywords = {cd4\_t\_cell, experimental, tania\_tb\_paper}, month = {February}, number = {2}, pages = {621--629}, posted-at = {2008-07-26 03:38:38}, priority = {2}, title = {CD4(+) T-cell subsets that mediate immunological memory to Mycobacterium tuberculosis infection in mice.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10639425}, volume = {68}, year = {2000} }

TY - JOUR ID - citeulike:3044174 L3 - citeulike-article-id:3044174 N2 - We have studied CD4(+) T cells that mediate immunological memory to an intravenous infection with Mycobacterium tuberculosis. The studies were conducted with a mouse model of memory immunity in which mice are rendered immune by a primary infection followed by antibiotic treatment and rest. Shortly after reinfection, tuberculosis-specific memory cells were recruited from the recirculating pool, leading to rapidly increasing precursor frequencies in the liver and a simultaneous decrease in the blood. A small subset of the infiltrating T cells was rapidly activated (<20 h) and expressed high levels of intracellular gamma interferon and the T-cell activation markers CD69 and CD25. These memory effector T cells expressed intermediate levels of CD45RB and were heterogeneous with regard to the L-selectin and CD44 markers. By adoptive transfer into nude mice, the highest level of resistance to a challenge with M. tuberculosis was mediated by CD45RB(high), L-selectin(high), CD44(low) cells. Taken together, these two lines of evidence support an important role for memory cells which have reverted to a naive phenotype in the long-term protection against M. tuberculosis. IS - 2 JF - Infection and immunity SN - 0019-9567 AD - Department of TB Immunology, Statens Serum Institut, Copenhagen, Denmark. pa@ssi.dk EP - 629 TI - CD4(+) T-cell subsets that mediate immunological memory to Mycobacterium tuberculosis infection in mice. VL - 68 SP - 621 KW - cd4_t_cell KW - experimental KW - tania_tb_paper AU - Andersen, P AU - Smedegaard, B PY - 2000/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/10639425 ER -