Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytes. Export

@article{citeulike:3058410, abstract = {The control of Mycobacterium tuberculosis (Mtb) infection is heavily dependent on the adaptive Th1 cellular immune response. Paradoxically, optimal priming of the Th1 response requires activation of priming dendritic cells with Th1 cytokine IFN-gamma. At present, the innate cellular mechanisms required for the generation of an optimal Th1 T cell response remain poorly characterized. We hypothesized that innate Mtb-reactive T cells provide an early source of IFN-gamma to fully activate Mtb-exposed dendritic cells. Here, we report the identification of a novel population of Mtb-reactive CD4(-) alphabetaTCR(+) innate thymocytes. These cells are present at high frequencies, respond to Mtb-infected cells by producing IFN-gamma directly ex vivo, and display characteristics of effector memory T cells. This novel innate population of Mtb-reactive T cells will drive further investigation into the role of these cells in the containment of Mtb following infectious exposure. Furthermore, this is the first demonstration of a human innate pathogen-specific alphabetaTCR(+) T cell and is likely to inspire further investigation into innate T cells recognizing other important human pathogens.}, address = {Department of Pulmonary and Critical Care Medicine, Portland VA Medical Center, Oregon Health and Science University, Portland, Oregon, United States of America. goldm@ohsu.edu}, author = {Gold, M. C. and Ehlinger, H. D. and Cook, M. S. and Smyk-Pearson, S. K. and Wille, P. T. and Ungerleider, R. M. and Lewinsohn, D. A. and Lewinsohn, D. M.}, citeulike-article-id = {3058410}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.ppat.0040039}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18282101}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18282101}, day = {8}, doi = {10.1371/journal.ppat.0040039}, issn = {1553-7374}, journal = {PLoS pathogens}, keywords = {innate\_immunol, tania\_tb\_paper, tuberculosis}, month = {February}, number = {2}, posted-at = {2008-07-30 06:50:51}, priority = {2}, title = {Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytes.}, url = {http://dx.doi.org/10.1371/journal.ppat.0040039}, volume = {4}, year = {2008} }

TY - JOUR ID - citeulike:3058410 L3 - citeulike-article-id:3058410 N2 - The control of Mycobacterium tuberculosis (Mtb) infection is heavily dependent on the adaptive Th1 cellular immune response. Paradoxically, optimal priming of the Th1 response requires activation of priming dendritic cells with Th1 cytokine IFN-gamma. At present, the innate cellular mechanisms required for the generation of an optimal Th1 T cell response remain poorly characterized. We hypothesized that innate Mtb-reactive T cells provide an early source of IFN-gamma to fully activate Mtb-exposed dendritic cells. Here, we report the identification of a novel population of Mtb-reactive CD4(-) alphabetaTCR(+) innate thymocytes. These cells are present at high frequencies, respond to Mtb-infected cells by producing IFN-gamma directly ex vivo, and display characteristics of effector memory T cells. This novel innate population of Mtb-reactive T cells will drive further investigation into the role of these cells in the containment of Mtb following infectious exposure. Furthermore, this is the first demonstration of a human innate pathogen-specific alphabetaTCR(+) T cell and is likely to inspire further investigation into innate T cells recognizing other important human pathogens. IS - 2 JF - PLoS pathogens SN - 1553-7374 AD - Department of Pulmonary and Critical Care Medicine, Portland VA Medical Center, Oregon Health and Science University, Portland, Oregon, United States of America. goldm@ohsu.edu TI - Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytes. VL - 4 KW - innate_immunol KW - tania_tb_paper KW - tuberculosis AU - Gold, MC AU - Ehlinger, HD AU - Cook, MS AU - Smyk-Pearson, SK AU - Wille, PT AU - Ungerleider, RM AU - Lewinsohn, DA AU - Lewinsohn, DM PY - 2008/02/08/ UR - http://dx.doi.org/10.1371/journal.ppat.0040039 ER -