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Profound peripheral T-lymphocyte depletion and activation in disseminated tuberculosis. Export

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, Vol. 10, No. 1. (February 2006), pp. 59-61.

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cd38 cd4_t_cell cd8_t_cell tania_tb_paper tuberculosis

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Three HIV-1-seronegative patients with disseminated tuberculosis presented significant depletion of T-cell counts, in CD4+ and/or CD8+ cells, associated with increased expression of activation marker CD38 on CD8+ T-lymphocytes. This finding raises the question of potential mechanisms involved in the activation or loss of T-cells in disseminated tuberculosis.


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