Antibody-dependent cell-mediated cytotoxicity (ADCC) in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) Export

@article{citeulike:3070055, abstract = {Defects in immune surveillance mechanisms may allow increased replication of human T-lymphotropic virus type I (HTLV-I) in peripheral blood mononuclear cells in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). To explore this possibility, antibody-dependent cell-mediated cytotoxicity (ADCC) against HTLV-I infected cells in HAM/TSP and in asymptomatic HTLV-I-seropositive carriers (SPC), was studied. ADCC activity was significantly depressed in HAM/TSP compared to SPC subjects (p < 0.025) and was due to specific reduction in ADCC effector activity. On the other hand, there was no difference in antibody component of anti-HTLV-I ADCC (ADCC-Ab) activities between HAM/TSP and SPC, although patients with more severe forms of disease tended to have higher anti-HTLV-I ADCC-Ab activity. In HAM/TSP, depressed ADCC activity against HTLV-I due to reduced ADCC-effector activity may allow increased replication of HTLV-I which may implicate the development of inflammatory neuropathologic lesions of HAM/TSP.}, address = {Department of Neurology, Kyushu University, Fukuoka, Japan.}, author = {Fujihara, K. and Itoyama, Y. and Yu, F. and Kubo, C. and Goto, I.}, citeulike-article-id = {3070055}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8902722}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8902722}, issn = {0022-510X}, journal = {Journal of the neurological sciences}, keywords = {adcc, hamtsp, translational\_hamtsp}, month = {October}, number = {1-2}, pages = {65--69}, posted-at = {2008-08-01 03:40:10}, priority = {2}, title = {Antibody-dependent cell-mediated cytotoxicity (ADCC) in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8902722}, volume = {142}, year = {1996} }

TY - JOUR ID - citeulike:3070055 L3 - citeulike-article-id:3070055 N2 - Defects in immune surveillance mechanisms may allow increased replication of human T-lymphotropic virus type I (HTLV-I) in peripheral blood mononuclear cells in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). To explore this possibility, antibody-dependent cell-mediated cytotoxicity (ADCC) against HTLV-I infected cells in HAM/TSP and in asymptomatic HTLV-I-seropositive carriers (SPC), was studied. ADCC activity was significantly depressed in HAM/TSP compared to SPC subjects (p < 0.025) and was due to specific reduction in ADCC effector activity. On the other hand, there was no difference in antibody component of anti-HTLV-I ADCC (ADCC-Ab) activities between HAM/TSP and SPC, although patients with more severe forms of disease tended to have higher anti-HTLV-I ADCC-Ab activity. In HAM/TSP, depressed ADCC activity against HTLV-I due to reduced ADCC-effector activity may allow increased replication of HTLV-I which may implicate the development of inflammatory neuropathologic lesions of HAM/TSP. IS - 1-2 JF - Journal of the neurological sciences SN - 0022-510X AD - Department of Neurology, Kyushu University, Fukuoka, Japan. EP - 69 TI - Antibody-dependent cell-mediated cytotoxicity (ADCC) in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) VL - 142 SP - 65 KW - adcc KW - hamtsp KW - translational_hamtsp AU - Fujihara, K AU - Itoyama, Y AU - Yu, F AU - Kubo, C AU - Goto, I PY - 1996/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/8902722 ER -