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Acute disseminated encephalomyelitis: clinical and pathogenesis features. Export

Neurologic clinics, Vol. 26, No. 3. (August 2008), pp. 759-780.

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acute_dissem_encephalomyelitis neurovirology pathogenesis review

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Acute disseminated encephalomyelitis (ADEM) is an immune-mediated disorder of the central nervous system (CNS). Disease typically starts with an abrupt onset of neurologic symptoms and signs within days to weeks after a viral infection or immunization. Neuropathological examination of the CNS in ADEM reveals involvement of white matter, with infiltration of monocytoid cells and perivenous demyelination.


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