How does HTLV-I persist despite a strong cell-mediated immune response? Export

@article{citeulike:3129773, abstract = {Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that infects human CD4(+) T lymphocytes. Despite its presence in T cells, HTLV-1 causes little overt immunosuppression. This host-virus relationship has therefore been exploited as an excellent model system for studying the dynamic interaction between a persistent retrovirus and the normal human immune system. We use a combination of mathematical and experimental techniques to identify key factors on both sides of the in vivo host-virus interaction that significantly determine HTLV-I proviral load and disease risk. We develop a model to describe how these factors interact to enable viral persistence.}, address = {Department of Immunology, Wright-Fleming Institute, Imperial College London, London, W2 1PG, UK. b.asquith@imperial.ac.uk}, author = {Asquith, B. and Bangham, C. R.}, citeulike-article-id = {3129773}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.it.2007.09.006}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18042431}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18042431}, doi = {10.1016/j.it.2007.09.006}, issn = {1471-4906}, journal = {Trends in immunology}, keywords = {hamtsp, htlv-1, htlv-1\_pvl, immunomodelling, immunopathogenesis}, month = {January}, number = {1}, pages = {4--11}, posted-at = {2008-08-17 14:06:16}, priority = {2}, title = {How does HTLV-I persist despite a strong cell-mediated immune response?}, url = {http://dx.doi.org/10.1016/j.it.2007.09.006}, volume = {29}, year = {2008} }

TY - JOUR ID - citeulike:3129773 L3 - citeulike-article-id:3129773 N2 - Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that infects human CD4(+) T lymphocytes. Despite its presence in T cells, HTLV-1 causes little overt immunosuppression. This host-virus relationship has therefore been exploited as an excellent model system for studying the dynamic interaction between a persistent retrovirus and the normal human immune system. We use a combination of mathematical and experimental techniques to identify key factors on both sides of the in vivo host-virus interaction that significantly determine HTLV-I proviral load and disease risk. We develop a model to describe how these factors interact to enable viral persistence. IS - 1 JF - Trends in immunology SN - 1471-4906 AD - Department of Immunology, Wright-Fleming Institute, Imperial College London, London, W2 1PG, UK. b.asquith@imperial.ac.uk EP - 11 TI - How does HTLV-I persist despite a strong cell-mediated immune response? VL - 29 SP - 4 KW - hamtsp KW - htlv-1 KW - htlv-1_pvl KW - immunomodelling KW - immunopathogenesis AU - Asquith, B AU - Bangham, CR PY - 2008/01// UR - http://dx.doi.org/10.1016/j.it.2007.09.006 ER -