Coaxing the liver into preventing autoimmune disease in the brain. Export

@article{citeulike:3346876, abstract = {The liver has several unique immunological properties that affect T cell activation and immune regulation. Recent studies have uncovered opportunities for the treatment of genetic disease by directing expression of the functional therapeutic protein to hepatocytes. In a new study in this issue of the JCI, L\"{u}th and colleagues demonstrate that hepatic expression of a brain protein is protective against neuroinflammatory disease in a mouse model of human MS (see the related article, doi:10.1172/JCI32132). Suppression of autoimmunity was dependent on transgene expression in the liver and was mediated by induction of antigen-specific CD4(+)CD25(+)Foxp3(+) Tregs. These findings suggest that the introduction of antigens to the liver may have potential as a preventative or therapeutic intervention for autoimmune disease.}, address = {Department of Pediatrics, University of Florida, Gainesville, Florida, USA.}, author = {Hoffman, Brad E E. and Herzog, Roland W W.}, citeulike-article-id = {3346876}, citeulike-linkout-0 = {http://dx.doi.org/10.1172/JCI37079}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18802483}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18802483}, day = {18}, doi = {10.1172/JCI37079}, issn = {0021-9738}, journal = {The Journal of clinical investigation}, keywords = {for\_print, liver, neuroinflamatory\_dis, treg}, month = {September}, posted-at = {2008-09-28 13:44:41}, priority = {5}, title = {Coaxing the liver into preventing autoimmune disease in the brain.}, url = {http://dx.doi.org/10.1172/JCI37079}, year = {2008} }

TY - JOUR ID - citeulike:3346876 L3 - citeulike-article-id:3346876 N2 - The liver has several unique immunological properties that affect T cell activation and immune regulation. Recent studies have uncovered opportunities for the treatment of genetic disease by directing expression of the functional therapeutic protein to hepatocytes. In a new study in this issue of the JCI, Lüth and colleagues demonstrate that hepatic expression of a brain protein is protective against neuroinflammatory disease in a mouse model of human MS (see the related article, doi:10.1172/JCI32132). Suppression of autoimmunity was dependent on transgene expression in the liver and was mediated by induction of antigen-specific CD4(+)CD25(+)Foxp3(+) Tregs. These findings suggest that the introduction of antigens to the liver may have potential as a preventative or therapeutic intervention for autoimmune disease. JF - The Journal of clinical investigation SN - 0021-9738 AD - Department of Pediatrics, University of Florida, Gainesville, Florida, USA. TI - Coaxing the liver into preventing autoimmune disease in the brain. KW - for_print KW - liver KW - neuroinflamatory_dis KW - treg AU - Hoffman, Brad E AU - Herzog, Roland W PY - 2008/09/18/ UR - http://dx.doi.org/10.1172/JCI37079 ER -