Role of NKT cells in allogeneic islet graft survival. Export

@article{citeulike:3466560, abstract = {Although NKT cells expressing CD1d-reactive TCR exerted protective role in autoimmune diseases, the regulatory function of CD1d-dependent NKT cells in alloimmune responses has not been investigated thoroughly. Here, we demonstrated the regulatory effects of NKT cells using a pancreas islet transplantation model. CD40/CD154 blocking induced long-term graft survival in most B6 recipients, but B6.CD1d(-/-) recipients showed co-stimulation blockade-resistant rejection. Adoptive transfer of NKT cells into B6.CD1d(-/-) restored tolerizing capacity of co-stimulatory blockade. Activation of NKT cells was effective for the prolongation of graft survival and up-regulated membrane-bound TGF-beta expression transiently on their cell surface. The activated CD1d-dependent NKT cells inhibited alloantigen-driven cell proliferation through cell contacts and the beneficial effect of CD154 blocking for allograft survival was related to TGF-beta pathway. Thus, we can conclude that NKT cells are essential for the stable allograft survival and the regulatory function is dependent on, at least in part, TGF-beta engagement.}, author = {Yang, S. H. and Jin, J. Z. and Lee, S. H. and Park, H. and Kim, C. H. and Lee, D. S. and Kim, S. and Chung, N. H. and Kim, Y. S.}, citeulike-article-id = {3466560}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.clim.2007.06.003}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17662658}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17662658}, doi = {10.1016/j.clim.2007.06.003}, issn = {1521-6616}, journal = {Clinical immunology (Orlando, Fla.)}, keywords = {nkt\_cell, transplantation, without\_pdf}, month = {September}, number = {3}, pages = {258--266}, posted-at = {2008-10-30 19:27:44}, priority = {2}, title = {Role of NKT cells in allogeneic islet graft survival.}, url = {http://dx.doi.org/10.1016/j.clim.2007.06.003}, volume = {124}, year = {2007} }

TY - JOUR ID - citeulike:3466560 L3 - citeulike-article-id:3466560 N2 - Although NKT cells expressing CD1d-reactive TCR exerted protective role in autoimmune diseases, the regulatory function of CD1d-dependent NKT cells in alloimmune responses has not been investigated thoroughly. Here, we demonstrated the regulatory effects of NKT cells using a pancreas islet transplantation model. CD40/CD154 blocking induced long-term graft survival in most B6 recipients, but B6.CD1d(-/-) recipients showed co-stimulation blockade-resistant rejection. Adoptive transfer of NKT cells into B6.CD1d(-/-) restored tolerizing capacity of co-stimulatory blockade. Activation of NKT cells was effective for the prolongation of graft survival and up-regulated membrane-bound TGF-beta expression transiently on their cell surface. The activated CD1d-dependent NKT cells inhibited alloantigen-driven cell proliferation through cell contacts and the beneficial effect of CD154 blocking for allograft survival was related to TGF-beta pathway. Thus, we can conclude that NKT cells are essential for the stable allograft survival and the regulatory function is dependent on, at least in part, TGF-beta engagement. IS - 3 JF - Clinical immunology (Orlando, Fla.) SN - 1521-6616 EP - 266 TI - Role of NKT cells in allogeneic islet graft survival. VL - 124 SP - 258 KW - nkt_cell KW - transplantation KW - without_pdf AU - Yang, SH AU - Jin, JZ AU - Lee, SH AU - Park, H AU - Kim, CH AU - Lee, DS AU - Kim, S AU - Chung, NH AU - Kim, YS PY - 2007/09// UR - http://dx.doi.org/10.1016/j.clim.2007.06.003 ER -