Different physiological MRI noise between cortical layers

@article{citeulike:2191787, abstract = {Significantly higher temporal fluctuations of the blood oxygenation level-dependent (BOLD) signal in the living rat group compared to that in the dead rat group were observed in the cortex, suggesting the existence of physiological information in the signal fluctuations. A similar analysis shows significantly different fluctuations between visual cortical layers. The highest fluctuations were observed in layers 4 and 5 and the lowest in layer 1. Given the consistency with published electrophysiology studies anticipating high spontaneous activity in the deeper layers (particularly layer 4), and low activity in superficial layers, we hypothesize that the BOLD signal temporal fluctuations may reflect cortical neuronal activity. Temporal fluctuations in ultrahigh spatial resolution data of the rat brain were measured in two ways. In the first, analyses were performed according to known layer widths, and in the second equal lines of 117 ? along the cortex were selected. The second approach yielded temporal fluctuations along the cortex that resemble known neuronal density distributions including the intralayer structure, particularly within layer 5. Magn Reson Med 52:913-916, 2004. {\copyright} 2004 Wiley-Liss, Inc.}, address = {MRI/MRS Lab, the Human Biology Research Center, Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel}, author = {Pelled, Galit and Goelman, Gadi }, citeulike-article-id = {2191787}, doi = {http://dx.doi.org/10.1002/mrm.20229}, journal = {Magnetic Resonance in Medicine}, keywords = {fluctuations}, number = {4}, pages = {913--916}, posted-at = {2008-01-03 16:43:20}, priority = {2}, title = {Different physiological MRI noise between cortical layers}, url = {http://dx.doi.org/10.1002/mrm.20229}, volume = {52}, year = {2004} }

TY - JOUR ID - citeulike:2191787 L3 - citeulike-article-id:2191787 TI - Different physiological MRI noise between cortical layers JF - Magnetic Resonance in Medicine VL - 52 IS - 4 SP - 913 EP - 916 AD - MRI/MRS Lab, the Human Biology Research Center, Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel N2 - Significantly higher temporal fluctuations of the blood oxygenation level-dependent (BOLD) signal in the living rat group compared to that in the dead rat group were observed in the cortex, suggesting the existence of physiological information in the signal fluctuations. A similar analysis shows significantly different fluctuations between visual cortical layers. The highest fluctuations were observed in layers 4 and 5 and the lowest in layer 1. Given the consistency with published electrophysiology studies anticipating high spontaneous activity in the deeper layers (particularly layer 4), and low activity in superficial layers, we hypothesize that the BOLD signal temporal fluctuations may reflect cortical neuronal activity. Temporal fluctuations in ultrahigh spatial resolution data of the rat brain were measured in two ways. In the first, analyses were performed according to known layer widths, and in the second equal lines of 117 ? along the cortex were selected. The second approach yielded temporal fluctuations along the cortex that resemble known neuronal density distributions including the intralayer structure, particularly within layer 5. Magn Reson Med 52:913-916, 2004. © 2004 Wiley-Liss, Inc. KW - fluctuations AU - Pelled, Galit AU - Goelman, Gadi PY - 2004/// UR - http://dx.doi.org/10.1002/mrm.20229 ER -