The operational characteristics of the Exhaust-Modulated Plasma Rocket are described. Four basic human and robotic mission scenarios to Mars are analyzed using numerical optimization techniques at variable specific impulse and constant power. The device is well-suited for “split-sprint” missions allowing fast, one-way low-payload human transits of 90 to 104 days, as well as slower, 180-day, high payload robotic precursor flights. Abort capabilities, essential for human missions, are also explored.