KAAS: an automatic genome annotation and pathway reconstruction server. Export

@article{citeulike:1626421, abstract = {The number of complete and draft genomes is rapidly growing in recent years, and it has become increasingly important to automate the identification of functional properties and biological roles of genes in these genomes. In the KEGG database, genes in complete genomes are annotated with the KEGG orthology (KO) identifiers, or the K numbers, based on the best hit information using Smith-Waterman scores as well as by the manual curation. Each K number represents an ortholog group of genes, and it is directly linked to an object in the KEGG pathway map or the BRITE functional hierarchy. Here, we have developed a web-based server called KAAS (KEGG Automatic Annotation Server: http://www.genome.jp/kegg/kaas/) i.e. an implementation of a rapid method to automatically assign K numbers to genes in the genome, enabling reconstruction of KEGG pathways and BRITE hierarchies. The method is based on sequence similarities, bi-directional best hit information and some heuristics, and has achieved a high degree of accuracy when compared with the manually curated KEGG GENES database.}, address = {Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.}, author = {Moriya, Yuki and Itoh, Masumi and Okuda, Shujiro and Yoshizawa, Akiyasu C. and Kanehisa, Minoru}, citeulike-article-id = {1626421}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/nar/gkm321}, citeulike-linkout-1 = {http://nar.oxfordjournals.org/content/35/suppl_2/W182.abstract}, citeulike-linkout-2 = {http://nar.oxfordjournals.org/content/35/suppl_2/W182.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/17526522}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=17526522}, day = {13}, doi = {10.1093/nar/gkm321}, issn = {1362-4962}, journal = {Nucleic acids research}, keywords = {ec, enzyme-prediction, kegg, metabolic-reconstruction}, month = {July}, number = {Web Server issue}, pages = {W182--185}, posted-at = {2009-04-03 01:19:43}, priority = {2}, title = {KAAS: an automatic genome annotation and pathway reconstruction server.}, url = {http://dx.doi.org/10.1093/nar/gkm321}, volume = {35}, year = {2007} }

TY - JOUR ID - citeulike:1626421 L3 - citeulike-article-id:1626421 N2 - The number of complete and draft genomes is rapidly growing in recent years, and it has become increasingly important to automate the identification of functional properties and biological roles of genes in these genomes. In the KEGG database, genes in complete genomes are annotated with the KEGG orthology (KO) identifiers, or the K numbers, based on the best hit information using Smith-Waterman scores as well as by the manual curation. Each K number represents an ortholog group of genes, and it is directly linked to an object in the KEGG pathway map or the BRITE functional hierarchy. Here, we have developed a web-based server called KAAS (KEGG Automatic Annotation Server: http://www.genome.jp/kegg/kaas/) i.e. an implementation of a rapid method to automatically assign K numbers to genes in the genome, enabling reconstruction of KEGG pathways and BRITE hierarchies. The method is based on sequence similarities, bi-directional best hit information and some heuristics, and has achieved a high degree of accuracy when compared with the manually curated KEGG GENES database. IS - Web Server issue JF - Nucleic acids research SN - 1362-4962 AD - Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. EP - 185 TI - KAAS: an automatic genome annotation and pathway reconstruction server. VL - 35 SP - W182 KW - ec KW - enzyme-prediction KW - kegg KW - metabolic-reconstruction AU - Moriya, Yuki AU - Itoh, Masumi AU - Okuda, Shujiro AU - Yoshizawa, Akiyasu AU - Kanehisa, Minoru PY - 2007/07/13/ UR - http://dx.doi.org/10.1093/nar/gkm321 ER -