Problems of somatic mutation and cancer. Export

@article{citeulike:4162729, abstract = {Somatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a cellular lineage, and the nature of competition between different cellular lineages. We consider how various aspects of tissue architecture and cellular competition affect the pace of mutation accumulation. We also discuss the rise and fall of somatic mutation rates during cancer progression.}, author = {Frank, S. A. and Nowak, M. A.}, citeulike-article-id = {4162729}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/bies.20000}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14988930}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14988930}, doi = {10.1002/bies.20000}, issn = {0265-9247}, journal = {BioEssays : news and reviews in molecular, cellular and developmental biology}, keywords = {cancer, evodynamics, evolution}, month = {March}, number = {3}, pages = {291--299}, posted-at = {2009-03-10 19:26:29}, priority = {2}, title = {Problems of somatic mutation and cancer.}, url = {http://dx.doi.org/10.1002/bies.20000}, volume = {26}, year = {2004} }

TY - JOUR ID - citeulike:4162729 L3 - citeulike-article-id:4162729 N2 - Somatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a cellular lineage, and the nature of competition between different cellular lineages. We consider how various aspects of tissue architecture and cellular competition affect the pace of mutation accumulation. We also discuss the rise and fall of somatic mutation rates during cancer progression. IS - 3 JF - BioEssays : news and reviews in molecular, cellular and developmental biology SN - 0265-9247 EP - 299 TI - Problems of somatic mutation and cancer. VL - 26 SP - 291 KW - cancer KW - evodynamics KW - evolution AU - Frank, SA AU - Nowak, MA PY - 2004/03// UR - http://dx.doi.org/10.1002/bies.20000 ER -