Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence Export

@article{citeulike:499778, abstract = {Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation. }, address = {Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK. stcole@pasteur.fr}, author = {Cole, S. T. and Brosch, R. and Parkhill, J. and Garnier, T. and Churcher, C. and Harris, D. and Gordon, S. V. and Eiglmeier, K. and Gas, S. and Barry, C. E. and Tekaia, F. and Badcock, K. and Basham, D. and Brown, D. and Chillingworth, T. and Connor, R. and Davies, R. and Devlin, K. and Feltwell, T. and Gentles, S. and Hamlin, N. and Holroyd, S. and Hornsby, T. and Jagels, K. and Krogh, A. and McLean, J. and Moule, S. and Murphy, L. and Oliver, K. and Osborne, J. and Quail, M. A. and Rajandream, M. A. and Rogers, J. and Rutter, S. and Seeger, K. and Skelton, J. and Squares, R. and Squares, S. and Sulston, J. E. and Taylor, K. and Whitehead, S. and Barrell, B. G.}, citeulike-article-id = {499778}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/31159}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/393537a0}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/9634230}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=9634230}, comment = {[27] desA1,2,3 UNK1}, day = {11}, doi = {10.1038/31159}, issn = {0028-0836}, journal = {Nature}, keywords = {desa, fatty-acid, tb}, month = {June}, number = {6685}, pages = {537--544}, posted-at = {2008-08-09 06:41:23}, priority = {2}, publisher = {Nature Publishing Group}, title = {Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence}, url = {http://dx.doi.org/10.1038/31159}, volume = {393}, year = {1998} }

TY - JOUR ID - citeulike:499778 L3 - citeulike-article-id:499778 N2 - Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation. IS - 6685 JF - Nature SN - 0028-0836 AD - Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK. stcole@pasteur.fr EP - 544 TI - Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence PB - Nature Publishing Group VL - 393 SP - 537 KW - desa KW - fatty-acid KW - tb N1 - [27] desA1,2,3 UNK1 AU - Cole, ST AU - Brosch, R AU - Parkhill, J AU - Garnier, T AU - Churcher, C AU - Harris, D AU - Gordon, SV AU - Eiglmeier, K AU - Gas, S AU - Barry, CE AU - Tekaia, F AU - Badcock, K AU - Basham, D AU - Brown, D AU - Chillingworth, T AU - Connor, R AU - Davies, R AU - Devlin, K AU - Feltwell, T AU - Gentles, S AU - Hamlin, N AU - Holroyd, S AU - Hornsby, T AU - Jagels, K AU - Krogh, A AU - McLean, J AU - Moule, S AU - Murphy, L AU - Oliver, K AU - Osborne, J AU - Quail, MA AU - Rajandream, MA AU - Rogers, J AU - Rutter, S AU - Seeger, K AU - Skelton, J AU - Squares, R AU - Squares, S AU - Sulston, JE AU - Taylor, K AU - Whitehead, S AU - Barrell, BG PY - 1998/06/11/ UR - http://dx.doi.org/10.1038/31159 ER -