DIETARY FAT CONTENT MODIFIES LIVER FAT IN OVERWEIGHT NON-DIABETIC SUBJECTS. Export

@article{citeulike:113859, abstract = {Background: Fat accumulation in the liver has been shown to be closely correlated with hepatic insulin resistance and features of insulin resistance, even independent of body weight. The reason for interindividual variation in liver fat content is unknown. Cross-sectional data suggest dietary fat content may influence liver fat but this possibility has not been directly tested in humans. Design and methods: Liver fat (proton spectroscopy), intra-abdominal and sc fat (MRI) and markers of insulin sensitivity (insulin, FFA, lipids) were determined in 10 normal, obese women (age 43 +/- 5 yr (mean+/-SD), BMI 33 +/- 4 kg/m(2), range 27-38 kg/m(2)) at baseline and after two two-week isocaloric periods containing either 16\% (low fat diet) or 56\% (high fat diet) of total energy as fat. Results: Liver fat at baseline averaged 10 +/- 7\%. It decreased by 20 +/- 9\% during the low fat diet and increased by 35 +/- 21\% during the high fat diet (P = 0.014 for liver fat after low vs. high fat diets, P = 0.042 for change in liver fat by the low vs. high fat diet). Fasting serum insulin averaged 70 +/- 41 pmol/l at baseline. It decreased to 60 +/- 24 pmol/l during the low fat diet (P = 0.007 vs. before low fat diet) and increased to 81 +/- 44 pmol/l during the high fat diet (P = 0.040 vs. before high fat diet, P = 0.005 for change in serum insulin during low vs. high fat diet). Serum lipids, FFA, intra-abdominal and sc fat masses were unchanged. Conclusion: These data suggest that the amount of dietary fat influences liver fat content.}, address = {Department of Medicine, Division of Diabetes, Obesity Research Unit, Department of Psychiatryand Department of Oncology, University of Helsinki, Helsinki, Finland, National Public Health Institute, Helsinki, Finland.}, author = {Westerbacka, Jukka and Lammi, Katriina and H\"{a}kkinen, Anna-Maija M. and Rissanen, Aila and Salminen, Irma and Aro, Antti and Yki-J\"{a}rvinen, Hannele}, citeulike-article-id = {113859}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/jc.2004-1983}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15741262}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15741262}, day = {1}, doi = {10.1210/jc.2004-1983}, issn = {0021-972X}, journal = {J Clin Endocrinol Metab}, keywords = {diabetes, dietary, fat, obesity}, month = {March}, posted-at = {2005-04-12 13:16:01}, priority = {2}, title = {DIETARY FAT CONTENT MODIFIES LIVER FAT IN OVERWEIGHT NON-DIABETIC SUBJECTS.}, url = {http://dx.doi.org/10.1210/jc.2004-1983}, year = {2005} }

TY - JOUR ID - citeulike:113859 L3 - citeulike-article-id:113859 N2 - Background: Fat accumulation in the liver has been shown to be closely correlated with hepatic insulin resistance and features of insulin resistance, even independent of body weight. The reason for interindividual variation in liver fat content is unknown. Cross-sectional data suggest dietary fat content may influence liver fat but this possibility has not been directly tested in humans. Design and methods: Liver fat (proton spectroscopy), intra-abdominal and sc fat (MRI) and markers of insulin sensitivity (insulin, FFA, lipids) were determined in 10 normal, obese women (age 43 +/- 5 yr (mean+/-SD), BMI 33 +/- 4 kg/m(2), range 27-38 kg/m(2)) at baseline and after two two-week isocaloric periods containing either 16% (low fat diet) or 56% (high fat diet) of total energy as fat. Results: Liver fat at baseline averaged 10 +/- 7%. It decreased by 20 +/- 9% during the low fat diet and increased by 35 +/- 21% during the high fat diet (P = 0.014 for liver fat after low vs. high fat diets, P = 0.042 for change in liver fat by the low vs. high fat diet). Fasting serum insulin averaged 70 +/- 41 pmol/l at baseline. It decreased to 60 +/- 24 pmol/l during the low fat diet (P = 0.007 vs. before low fat diet) and increased to 81 +/- 44 pmol/l during the high fat diet (P = 0.040 vs. before high fat diet, P = 0.005 for change in serum insulin during low vs. high fat diet). Serum lipids, FFA, intra-abdominal and sc fat masses were unchanged. Conclusion: These data suggest that the amount of dietary fat influences liver fat content. JF - J Clin Endocrinol Metab SN - 0021-972X AD - Department of Medicine, Division of Diabetes, Obesity Research Unit, Department of Psychiatryand Department of Oncology, University of Helsinki, Helsinki, Finland, National Public Health Institute, Helsinki, Finland. TI - DIETARY FAT CONTENT MODIFIES LIVER FAT IN OVERWEIGHT NON-DIABETIC SUBJECTS. KW - diabetes KW - dietary KW - fat KW - obesity AU - Westerbacka, Jukka AU - Lammi, Katriina AU - Häkkinen, Anna-Maija AU - Rissanen, Aila AU - Salminen, Irma AU - Aro, Antti AU - Yki-Järvinen, Hannele PY - 2005/03/01/ UR - http://dx.doi.org/10.1210/jc.2004-1983 ER -