Resveratrol inhibits MMP-9 expression by up-regulating PPAR alpha expression in an oxygen glucose deprivation-exposed neuron model. Export

@article{citeulike:3885443, abstract = {Resveratrol (trans-3,4',5-trihydroxystilbene, Res) is a natural polyphenol. A recent experiment confirmed that Res can selectively activate both peroxisome proliferators-activated receptors (PPAR) alpha and gamma. In addition, Res can protect neurons by matrix metalloproteinase-9 (MMP-9) down-regulation. The relationship between Res, MMP-9 and PPAR alpha or gamma was studied in an oxygen and glucose deprivation-exposed neuron model. It showed that Res can inhibit mRNA and protein expression of MMP-9, while it up-regulates the expression of PPAR alpha and gamma. The effect of Res on both PPAR alpha and MMP-9 can be offset partially by MK886. However, PPAR gamma antagonist GW9662 had little effect on MMP-9 expression. These results suggest that Res can inhibit MMP-9 expression by up-regulating PPAR alpha.}, author = {Cheng, Gang and Zhang, Xiang and Gao, Dakuan and Jiang, Xiaofan and Dong, Wenpeng}, citeulike-article-id = {3885443}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neulet.2008.12.045}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19135132}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19135132}, day = {27}, doi = {10.1016/j.neulet.2008.12.045}, issn = {0304-3940}, journal = {Neuroscience letters}, keywords = {matrix\_metalloproteinase, mmp, mmp-9, ppar\_alpha, resveratrol}, month = {December}, posted-at = {2009-08-24 07:19:02}, priority = {2}, title = {Resveratrol inhibits MMP-9 expression by up-regulating PPAR alpha expression in an oxygen glucose deprivation-exposed neuron model.}, url = {http://dx.doi.org/10.1016/j.neulet.2008.12.045}, year = {2008} }

TY - JOUR ID - citeulike:3885443 L3 - citeulike-article-id:3885443 N2 - Resveratrol (trans-3,4',5-trihydroxystilbene, Res) is a natural polyphenol. A recent experiment confirmed that Res can selectively activate both peroxisome proliferators-activated receptors (PPAR) alpha and gamma. In addition, Res can protect neurons by matrix metalloproteinase-9 (MMP-9) down-regulation. The relationship between Res, MMP-9 and PPAR alpha or gamma was studied in an oxygen and glucose deprivation-exposed neuron model. It showed that Res can inhibit mRNA and protein expression of MMP-9, while it up-regulates the expression of PPAR alpha and gamma. The effect of Res on both PPAR alpha and MMP-9 can be offset partially by MK886. However, PPAR gamma antagonist GW9662 had little effect on MMP-9 expression. These results suggest that Res can inhibit MMP-9 expression by up-regulating PPAR alpha. JF - Neuroscience letters SN - 0304-3940 TI - Resveratrol inhibits MMP-9 expression by up-regulating PPAR alpha expression in an oxygen glucose deprivation-exposed neuron model. KW - matrix_metalloproteinase KW - mmp KW - mmp-9 KW - ppar_alpha KW - resveratrol AU - Cheng, Gang AU - Zhang, Xiang AU - Gao, Dakuan AU - Jiang, Xiaofan AU - Dong, Wenpeng PY - 2008/12/27/ UR - http://dx.doi.org/10.1016/j.neulet.2008.12.045 ER -