Logical analysis of the budding yeast cell cycle Export

@article{citeulike:4269568, abstract = {The budding yeast Saccharomyces cerevisiae is a model organism that is commonly used to investigate control of the eukaryotic cell cycle. Moreover, because of the extensive experimental data on wild type and mutant phenotypes, it is also particularly suitable for mathematical modelling and analysis. Here, I present a new Boolean model of the budding yeast cell cycle. This model is consistent with a wide range of wild type and mutant phenotypes and shows remarkable robustness against perturbations, both to reaction times and the states of component genes/proteins. Because of its simple logical nature, the model is suitable for sub-network analysis, which can be used to identify a four node core regulatory circuit underlying cell cycle regulation. Sub-network analysis can also be used to identify key sub-dynamics that are essential for viable cell cycle control, as well as identifying the sub-dynamics that are most variable between different mutants.}, author = {Irons, D. J.}, citeulike-article-id = {4269568}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jtbi.2008.12.028}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0022519308006619}, doi = {10.1016/j.jtbi.2008.12.028}, issn = {00225193}, journal = {Journal of Theoretical Biology}, keywords = {cell\_cycle}, month = {April}, number = {4}, pages = {543--559}, posted-at = {2009-04-03 11:04:15}, priority = {2}, title = {Logical analysis of the budding yeast cell cycle}, url = {http://dx.doi.org/10.1016/j.jtbi.2008.12.028}, volume = {257}, year = {2009} }

TY - JOUR ID - citeulike:4269568 L3 - citeulike-article-id:4269568 N2 - The budding yeast Saccharomyces cerevisiae is a model organism that is commonly used to investigate control of the eukaryotic cell cycle. Moreover, because of the extensive experimental data on wild type and mutant phenotypes, it is also particularly suitable for mathematical modelling and analysis. Here, I present a new Boolean model of the budding yeast cell cycle. This model is consistent with a wide range of wild type and mutant phenotypes and shows remarkable robustness against perturbations, both to reaction times and the states of component genes/proteins. Because of its simple logical nature, the model is suitable for sub-network analysis, which can be used to identify a four node core regulatory circuit underlying cell cycle regulation. Sub-network analysis can also be used to identify key sub-dynamics that are essential for viable cell cycle control, as well as identifying the sub-dynamics that are most variable between different mutants. IS - 4 JF - Journal of Theoretical Biology SN - 00225193 EP - 559 TI - Logical analysis of the budding yeast cell cycle VL - 257 SP - 543 KW - cell_cycle AU - Irons, DJ PY - 2009/04/21/ UR - http://dx.doi.org/10.1016/j.jtbi.2008.12.028 ER -