Advantage of having regulatory T cells requires localized suppression of immune reactions Export

@article{citeulike:5314108, abstract = {The immune system of vertebrates may attack its own body and cause autoimmunity diseases. To prevent autoimmunity, regulatory T cells suppress the activity of the autoreactive effector T cells, but they also interrupt normal immune reactions against foreign antigens. In this paper, we discuss the advantage of having some regulatory T cells by considering the host's ability of coping with foreign antigens and the harm of autoimmunity. Assumptions are as follows: the immature T cells reactive to abundant self-antigens are eliminated, those reactive to rare self-antigen will become regulatory T cells, and those that fail to interact with the antigens to which they are reactive will become effector T cells. Some self-reactive immature T cells may fail to interact with their own target antigens during the limited training period, and will later become effector T cells, causing autoimmunity. Analysis suggests that, having some regulatory T cells can never be advantageous to the host, if activated regulatory T cells suppress effector T cells at any location of the body (global suppression). In contrast, producing some regulatory T cells can be beneficial, if the body is composed of many compartments and regulatory T cells suppress the immune reactions only within the same compartment (localized suppression). This requires regulatory T cells to stop circulating once they are activated by their own target self-antigens.}, author = {Saeki, Koichi and Iwasa, Yoh}, citeulike-article-id = {5314108}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jtbi.2009.06.020}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0022519309002975}, day = {07}, doi = {10.1016/j.jtbi.2009.06.020}, issn = {00225193}, journal = {Journal of Theoretical Biology}, month = {October}, number = {3}, pages = {392--401}, posted-at = {2009-09-11 18:43:50}, priority = {2}, title = {Advantage of having regulatory T cells requires localized suppression of immune reactions}, url = {http://dx.doi.org/10.1016/j.jtbi.2009.06.020}, volume = {260}, year = {2009} }

TY - JOUR ID - citeulike:5314108 L3 - citeulike-article-id:5314108 N2 - The immune system of vertebrates may attack its own body and cause autoimmunity diseases. To prevent autoimmunity, regulatory T cells suppress the activity of the autoreactive effector T cells, but they also interrupt normal immune reactions against foreign antigens. In this paper, we discuss the advantage of having some regulatory T cells by considering the host's ability of coping with foreign antigens and the harm of autoimmunity. Assumptions are as follows: the immature T cells reactive to abundant self-antigens are eliminated, those reactive to rare self-antigen will become regulatory T cells, and those that fail to interact with the antigens to which they are reactive will become effector T cells. Some self-reactive immature T cells may fail to interact with their own target antigens during the limited training period, and will later become effector T cells, causing autoimmunity. Analysis suggests that, having some regulatory T cells can never be advantageous to the host, if activated regulatory T cells suppress effector T cells at any location of the body (global suppression). In contrast, producing some regulatory T cells can be beneficial, if the body is composed of many compartments and regulatory T cells suppress the immune reactions only within the same compartment (localized suppression). This requires regulatory T cells to stop circulating once they are activated by their own target self-antigens. IS - 3 JF - Journal of Theoretical Biology SN - 00225193 EP - 401 TI - Advantage of having regulatory T cells requires localized suppression of immune reactions VL - 260 SP - 392 AU - Saeki, Koichi AU - Iwasa, Yoh PY - 2009/10/07/ UR - http://dx.doi.org/10.1016/j.jtbi.2009.06.020 ER -