Rhodopsin: Structure, signal transduction and oligomerisation Export

@article{citeulike:4908384, abstract = {Rhodopsin was the first G protein-coupled receptor (GPCR) for which a high-resolution crystal structure was obtained. Several crystal structures have now been solved representing different activation states of the receptor. These structures, together with those from lower resolution techniques (e.g. electron microscopy), shed light on the stepwise process by which energy from an extracellular photon is transduced across the membrane to the intracellular compartment thereby activating signalling mechanisms responsible for very low-level light detection. Controversy remains in several areas including: (i) transmembrane helix movements responsible for the transduction process, (ii) the stoichiometry of coupling to G proteins and their mode of activation, (iii) the role, if any, of receptor oligomerisation and (iv) the suitability of using structures of this GPCR as templates for modelling the structures of other GPCRs, and their mechanisms of activation.}, author = {Morris, Michael B. and Dastmalchi, Siavoush and Church, Bret W.}, citeulike-article-id = {4908384}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.biocel.2008.04.025}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S135727250800157X}, doi = {10.1016/j.biocel.2008.04.025}, issn = {13572725}, journal = {The International Journal of Biochemistry \& Cell Biology}, keywords = {gpcr, rhodopsin}, month = {April}, number = {4}, pages = {721--724}, posted-at = {2009-06-19 15:36:38}, priority = {0}, title = {Rhodopsin: Structure, signal transduction and oligomerisation}, url = {http://dx.doi.org/10.1016/j.biocel.2008.04.025}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:4908384 L3 - citeulike-article-id:4908384 N2 - Rhodopsin was the first G protein-coupled receptor (GPCR) for which a high-resolution crystal structure was obtained. Several crystal structures have now been solved representing different activation states of the receptor. These structures, together with those from lower resolution techniques (e.g. electron microscopy), shed light on the stepwise process by which energy from an extracellular photon is transduced across the membrane to the intracellular compartment thereby activating signalling mechanisms responsible for very low-level light detection. Controversy remains in several areas including: (i) transmembrane helix movements responsible for the transduction process, (ii) the stoichiometry of coupling to G proteins and their mode of activation, (iii) the role, if any, of receptor oligomerisation and (iv) the suitability of using structures of this GPCR as templates for modelling the structures of other GPCRs, and their mechanisms of activation. IS - 4 JF - The International Journal of Biochemistry & Cell Biology SN - 13572725 EP - 724 TI - Rhodopsin: Structure, signal transduction and oligomerisation VL - 41 SP - 721 KW - gpcr KW - rhodopsin AU - Morris, Michael AU - Dastmalchi, Siavoush AU - Church, Bret PY - 2009/04// UR - http://dx.doi.org/10.1016/j.biocel.2008.04.025 ER -