A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction. Export

@article{citeulike:5656640, abstract = {We have isolated and analyzed a cDNA from the central nervous system of the mollusc Lymnaea stagnalis encoding a putative receptor, which might be a natural hybrid between two different classes of receptor proteins. Preceded by a signal peptide, two types of repeated sequences are present in the N-terminal part of the protein. The first repeat displays a high sequence similarity to the extracellular binding domains of the low density lipoprotein receptor, which binds and internalizes cholesterol-containing apolipoproteins. The second repeat and the C-terminal part of the Lymnaea receptor are very similar to regions of a specific class of guanine nucleotide-binding protein-coupled receptors, the mammalian glycoprotein hormone receptors. The mRNA encoding the receptor is predominantly expressed in a small number of neurons within the central nervous system and to a lesser extent in the heart.}, author = {Tensen, C. P. and Van Kesteren, E. R. and Planta, R. J. and Cox, K. J. and Burke, J. F. and van Heerikhuizen, H. and Vreugdenhil, E.}, citeulike-article-id = {5656640}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8197140}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8197140}, day = {24}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {gpcr, lipoprotein, lymne}, month = {May}, number = {11}, pages = {4816--4820}, posted-at = {2009-08-27 12:56:44}, priority = {2}, title = {A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8197140}, volume = {91}, year = {1994} }

TY - JOUR ID - citeulike:5656640 L3 - citeulike-article-id:5656640 N2 - We have isolated and analyzed a cDNA from the central nervous system of the mollusc Lymnaea stagnalis encoding a putative receptor, which might be a natural hybrid between two different classes of receptor proteins. Preceded by a signal peptide, two types of repeated sequences are present in the N-terminal part of the protein. The first repeat displays a high sequence similarity to the extracellular binding domains of the low density lipoprotein receptor, which binds and internalizes cholesterol-containing apolipoproteins. The second repeat and the C-terminal part of the Lymnaea receptor are very similar to regions of a specific class of guanine nucleotide-binding protein-coupled receptors, the mammalian glycoprotein hormone receptors. The mRNA encoding the receptor is predominantly expressed in a small number of neurons within the central nervous system and to a lesser extent in the heart. IS - 11 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 EP - 4820 TI - A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction. VL - 91 SP - 4816 KW - gpcr KW - lipoprotein KW - lymne AU - Tensen, CP AU - Van Kesteren, ER AU - Planta, RJ AU - Cox, KJ AU - Burke, JF AU - van Heerikhuizen, H AU - Vreugdenhil, E PY - 1994/05/24/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8197140 ER -