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Molecular Recognition by Induced Fit: How Fit is the Concept?

by: Hans R. Bosshard
Physiology, Vol. 16, No. 4. (01 August 2001), pp. 171-173  Key: citeulike:4543105

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Abstract

Induced fit explains why biomolecules can bind together even if they are not optimized for binding. However, induced fit can lead to a kinetic bottleneck and does not describe every interaction in the absence of prior complementarity. Preselection of a fitting conformer is an alternative to induced fit.


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