Conotoxins: From the biodiversity of gastropods to new drugs
The review describes general trends in research of conotoxins, the peptide toxins isolated from sea gastropods of the genus Conus . It covers publications from conotoxin discovery in 1970th up to contemporary research and considers classification of conotoxins, their structural diversity and different ways of their action on molecular targets, particularly, ion channels. Special attention is paid to the applied aspect of conotoxin research especially to perspectives of the development of conotoxin based drugs. The first example of such conotoxin based drug is ziconotide an analgesic of a new generation.