Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline. Export

@article{citeulike:3284226, abstract = {During the development of multicellular organisms, the processes of growth and differentiation are kept in balance to generate and maintain tissues and organs of the correct size, shape and cellular composition. We have investigated the molecular controls of growth and differentiation in the Caenorhabditis elegans germline. A single somatic cell, called the distal tip cell, promotes mitotic proliferation in the adjacent germline by GLP-1/Notch signaling. Within the germline, the decisions between mitosis and meiosis and between spermatogenesis and oogenesis are controlled by a group of conserved RNA regulators. FBF, a member of the PUF (for Pumilio and FBF) family of RNA-binding proteins, promotes mitosis by repressing gld-1 mRNA activity; the GLD-1, GLD-2, GLD-3, and NOS-3 proteins promote entry into meiosis by regulating mRNAs that remain unknown. The regulatory balance between opposing FBF and GLD activities is crucial for controlling the extent of germline proliferation. PUF proteins regulate germline stem cells in both Drosophila and C. elegans and are localized to germline stem cells of the mammalian testis. Therefore, this post-transcriptional regulatory switch may be an ancient mechanism for controlling maintenance of stem cells versus differentiation.}, author = {Crittenden, S. L. and Eckmann, C. R. and Wang, L. and Bernstein, D. S. and Wickens, M. and Kimble, J.}, citeulike-article-id = {3284226}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rstb.2003.1333}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14511482}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14511482}, citeulike-linkout-3 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00006073}, doi = {10.1098/rstb.2003.1333}, journal = {Philosophical Transactions of the Royal Society of London}, keywords = {celegans, germcell, nanos, stemcell}, pages = {1359--1362}, posted-at = {2008-12-04 15:09:30}, priority = {2}, title = {Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline.}, url = {http://dx.doi.org/10.1098/rstb.2003.1333}, volume = {358B}, year = {2003} }

TY - JOUR ID - citeulike:3284226 L3 - citeulike-article-id:3284226 N2 - During the development of multicellular organisms, the processes of growth and differentiation are kept in balance to generate and maintain tissues and organs of the correct size, shape and cellular composition. We have investigated the molecular controls of growth and differentiation in the Caenorhabditis elegans germline. A single somatic cell, called the distal tip cell, promotes mitotic proliferation in the adjacent germline by GLP-1/Notch signaling. Within the germline, the decisions between mitosis and meiosis and between spermatogenesis and oogenesis are controlled by a group of conserved RNA regulators. FBF, a member of the PUF (for Pumilio and FBF) family of RNA-binding proteins, promotes mitosis by repressing gld-1 mRNA activity; the GLD-1, GLD-2, GLD-3, and NOS-3 proteins promote entry into meiosis by regulating mRNAs that remain unknown. The regulatory balance between opposing FBF and GLD activities is crucial for controlling the extent of germline proliferation. PUF proteins regulate germline stem cells in both Drosophila and C. elegans and are localized to germline stem cells of the mammalian testis. Therefore, this post-transcriptional regulatory switch may be an ancient mechanism for controlling maintenance of stem cells versus differentiation. JF - Philosophical Transactions of the Royal Society of London EP - 1362 TI - Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline. VL - 358B SP - 1359 KW - celegans KW - germcell KW - nanos KW - stemcell AU - Crittenden, SL AU - Eckmann, CR AU - Wang, L AU - Bernstein, DS AU - Wickens, M AU - Kimble, J PY - 2003/// UR - http://dx.doi.org/10.1098/rstb.2003.1333 ER -