TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB. Export

@article{citeulike:4509371, abstract = {The transcription factor NF-kappaB is important for expression of genes involved in immune responses, viral infections, cytokine signaling and stress. In addition NF-kappaB plays a crucial role in protecting cells from TNF-alpha-induced apoptotic stimuli, presumably by activating anti-apoptotic genes. Here we report that the sub-stoichiometric TFIID subunit TAFII105 is essential for activation of anti-apoptotic genes in response to TNF-alpha, serving as a transcriptional coactivator for NF-kappaB. The putative coactivator domain of TAFII105 interacts with the activation domain of the p65/RelA member of the NF-kappaB family, and further stimulates p65-induced transcription in human 293 cells. Moreover, inhibition of TAFII105 activity by overexpression of a dominant negative mutant of TAFII105 decreased NF-kappaB transcriptional activity and severely reduced cell survival in response to TNF-alpha. Similarly, expression of anti-sense TAFII105 RNA sensitized the cells to TNF-alpha cytotoxicity. These results suggest that TAFII105 is involved in activation of anti-apoptotic genes by NF-kappaB.}, author = {Yamit-Hezi, A. and Dikstein, R.}, citeulike-article-id = {4509371}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9724652}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9724652}, day = {1}, issn = {0261-4189}, journal = {The EMBO journal}, keywords = {nfkb, tafii105}, month = {September}, number = {17}, pages = {5161--5169}, posted-at = {2009-05-13 07:56:13}, priority = {2}, title = {TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9724652}, volume = {17}, year = {1998} }

TY - JOUR ID - citeulike:4509371 L3 - citeulike-article-id:4509371 N2 - The transcription factor NF-kappaB is important for expression of genes involved in immune responses, viral infections, cytokine signaling and stress. In addition NF-kappaB plays a crucial role in protecting cells from TNF-alpha-induced apoptotic stimuli, presumably by activating anti-apoptotic genes. Here we report that the sub-stoichiometric TFIID subunit TAFII105 is essential for activation of anti-apoptotic genes in response to TNF-alpha, serving as a transcriptional coactivator for NF-kappaB. The putative coactivator domain of TAFII105 interacts with the activation domain of the p65/RelA member of the NF-kappaB family, and further stimulates p65-induced transcription in human 293 cells. Moreover, inhibition of TAFII105 activity by overexpression of a dominant negative mutant of TAFII105 decreased NF-kappaB transcriptional activity and severely reduced cell survival in response to TNF-alpha. Similarly, expression of anti-sense TAFII105 RNA sensitized the cells to TNF-alpha cytotoxicity. These results suggest that TAFII105 is involved in activation of anti-apoptotic genes by NF-kappaB. IS - 17 JF - The EMBO journal SN - 0261-4189 EP - 5169 TI - TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB. VL - 17 SP - 5161 KW - nfkb KW - tafii105 AU - Yamit-Hezi, A AU - Dikstein, R PY - 1998/09/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9724652 ER -