Mechanisms of iron loading and toxicity Export

@article{citeulike:3665445, abstract = {Normal iron homeostasis is a finely balanced system that reflects iron absorption, loss and utilization. The body has no mechanism for the active excretion of iron, so body iron levels are controlled at the point of absorption in the small intestine. Disturbances in this equilibrium, such as those leading to enhanced absorption, can have significant clinical consequences. Continued excessive iron uptake is followed by iron deposition in various tissues, ultimately leading to tissue damage, and possibly end-organ failure. In this review, current concepts in normal iron homeostasis, and iron loading are explained. The clinical consequences as well as the differences between primary and secondary iron loading are also reviewed, and some future research priorities are discussed. Am. J. Hematol., 2007. {\copyright} 2007 Wiley-Liss, Inc.}, address = {Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane Queensland, Australia}, author = {Anderson, Gregory J.}, citeulike-article-id = {3665445}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/ajh.21075}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/116835824/ABSTRACT}, doi = {10.1002/ajh.21075}, journal = {American Journal of Hematology}, number = {S12}, pages = {1128--1131}, posted-at = {2008-11-23 12:46:24}, priority = {3}, title = {Mechanisms of iron loading and toxicity}, url = {http://dx.doi.org/10.1002/ajh.21075}, volume = {82}, year = {2007} }

TY - JOUR ID - citeulike:3665445 L3 - citeulike-article-id:3665445 N2 - Normal iron homeostasis is a finely balanced system that reflects iron absorption, loss and utilization. The body has no mechanism for the active excretion of iron, so body iron levels are controlled at the point of absorption in the small intestine. Disturbances in this equilibrium, such as those leading to enhanced absorption, can have significant clinical consequences. Continued excessive iron uptake is followed by iron deposition in various tissues, ultimately leading to tissue damage, and possibly end-organ failure. In this review, current concepts in normal iron homeostasis, and iron loading are explained. The clinical consequences as well as the differences between primary and secondary iron loading are also reviewed, and some future research priorities are discussed. Am. J. Hematol., 2007. © 2007 Wiley-Liss, Inc. IS - S12 JF - American Journal of Hematology AD - Iron Metabolism Laboratory, Queensland Institute of Medical Research, Brisbane Queensland, Australia EP - 1131 TI - Mechanisms of iron loading and toxicity VL - 82 SP - 1128 AU - Anderson, Gregory PY - 2007/// UR - http://dx.doi.org/10.1002/ajh.21075 ER -