On the human sensorimotor-cortex beta rhythm: sources and modeling. Export

@article{citeulike:579580, abstract = {Cortical oscillations in the beta band (13-35 Hz) are known to be modulated by the GABAergic agonist benzodiazepine. To investigate the mechanisms generating the approximately 20-Hz oscillations in the human cortex, we administered benzodiazepines to healthy adults and monitored cortical oscillatory activity by means of magnetoencephalography. Benzodiazepine increased the power and decreased the frequency of beta oscillations over rolandic areas. Minimum current estimates indicated the effect to take place around the hand area of the primary sensorimotor cortex. Given that previous research has identified sources of the beta rhythm in the motor cortex, our results suggest that these same motor-cortex beta sources are modulated by benzodiazepine. To explore the mechanisms underlying the increase in beta power with GABAergic inhibition, we simulated a conductance-based neuronal network comprising excitatory and inhibitory neurons. The model accounts for the increase in the beta power, the widening of the spectral peak, and the slowing down of the rhythms with benzodiazepines, implemented as an increase in GABAergic conductance. We found that an increase in IPSCs onto inhibitory neurons was more important for generating neuronal synchronization in the beta band than an increase in IPSCs onto excitatory pyramidal cells.}, address = {Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, Finland. ole.jensen@fcdonders.ru.nl}, author = {Jensen, O. and Goel, P. and Kopell, N. and Pohja, M. and Hari, R. and Ermentrout, B.}, citeulike-article-id = {579580}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuroimage.2005.02.008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15907295}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15907295}, doi = {10.1016/j.neuroimage.2005.02.008}, issn = {1053-8119}, journal = {Neuroimage}, keywords = {automaticity, beta-rhythm, cortex, ensemble, hz, inhib-ex-ci, motor, nnet, production, sensorimotor, synchronization}, month = {June}, number = {2}, pages = {347--355}, posted-at = {2008-08-28 12:31:27}, priority = {2}, title = {On the human sensorimotor-cortex beta rhythm: sources and modeling.}, url = {http://dx.doi.org/10.1016/j.neuroimage.2005.02.008}, volume = {26}, year = {2005} }

TY - JOUR ID - citeulike:579580 L3 - citeulike-article-id:579580 N2 - Cortical oscillations in the beta band (13-35 Hz) are known to be modulated by the GABAergic agonist benzodiazepine. To investigate the mechanisms generating the approximately 20-Hz oscillations in the human cortex, we administered benzodiazepines to healthy adults and monitored cortical oscillatory activity by means of magnetoencephalography. Benzodiazepine increased the power and decreased the frequency of beta oscillations over rolandic areas. Minimum current estimates indicated the effect to take place around the hand area of the primary sensorimotor cortex. Given that previous research has identified sources of the beta rhythm in the motor cortex, our results suggest that these same motor-cortex beta sources are modulated by benzodiazepine. To explore the mechanisms underlying the increase in beta power with GABAergic inhibition, we simulated a conductance-based neuronal network comprising excitatory and inhibitory neurons. The model accounts for the increase in the beta power, the widening of the spectral peak, and the slowing down of the rhythms with benzodiazepines, implemented as an increase in GABAergic conductance. We found that an increase in IPSCs onto inhibitory neurons was more important for generating neuronal synchronization in the beta band than an increase in IPSCs onto excitatory pyramidal cells. IS - 2 JF - Neuroimage SN - 1053-8119 AD - Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, Finland. ole.jensen@fcdonders.ru.nl EP - 355 TI - On the human sensorimotor-cortex beta rhythm: sources and modeling. VL - 26 SP - 347 KW - automaticity KW - beta-rhythm KW - cortex KW - ensemble KW - hz KW - inhib-ex-ci KW - motor KW - nnet KW - production KW - sensorimotor KW - synchronization AU - Jensen, O AU - Goel, P AU - Kopell, N AU - Pohja, M AU - Hari, R AU - Ermentrout, B PY - 2005/06// UR - http://dx.doi.org/10.1016/j.neuroimage.2005.02.008 ER -