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Nature Medicine, Vol. 19, No. 1. (09 December 2012), pp. 93-100, doi:10.1038/nm.3026 Key: citeulike:11878078
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In a new study Yingxian Li and her colleagues show that the microRNA miR-214 targets ATF4 in osteoblasts to negatively regulate their activity. Manipulating miR-214 levels experimentally showed that its elevated expression is sufficient to induce bone loss in mice and that its therapeutic inhibition reduces bone loss in two mouse models.
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