Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional represssor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1. Export

@article{citeulike:3888876, abstract = {The transcription of meiosis-specific genes, as well as the initiation of meiosis, in the budding yeast Saccharomyces cerevisiae depends on IME1. IME1 encodes a transcriptional activator which lacks known DNA binding motifs. In this study we have determined the mode by which Ime1 specifically activates the transcription of meiotic genes. We demonstrate that Ime1 is recruited to the promoters of meiotic genes by interacting with a DNA-binding protein, Ume6. This association between Ime1 and Ume6 depends on both starvation and the activity of a protein kinase, encoded by RIM11 In the absence of Ime1, Ume6 represses the transcription of meiotic genes. However, in the presence of Ime1, or when Ume6 is fused in frame to the Gal4 activation domain, Ume6 is converted from a repressor to an activator, resulting in the transcription of meiosis-specific genes and the formation of asci.}, author = {Rubin-Bejerano, I. and Mandel, S. and Robzyk, K. and Kassir, Y.}, citeulike-article-id = {3888876}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8628320}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8628320}, issn = {0270-7306}, journal = {Molecular and cellular biology}, keywords = {ime1, meiosis, meiosis\_regulation, sporulation, ume6}, month = {May}, number = {5}, pages = {2518--2526}, posted-at = {2009-01-15 14:17:22}, priority = {2}, title = {Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional represssor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8628320}, volume = {16}, year = {1996} }

TY - JOUR ID - citeulike:3888876 L3 - citeulike-article-id:3888876 N2 - The transcription of meiosis-specific genes, as well as the initiation of meiosis, in the budding yeast Saccharomyces cerevisiae depends on IME1. IME1 encodes a transcriptional activator which lacks known DNA binding motifs. In this study we have determined the mode by which Ime1 specifically activates the transcription of meiotic genes. We demonstrate that Ime1 is recruited to the promoters of meiotic genes by interacting with a DNA-binding protein, Ume6. This association between Ime1 and Ume6 depends on both starvation and the activity of a protein kinase, encoded by RIM11 In the absence of Ime1, Ume6 represses the transcription of meiotic genes. However, in the presence of Ime1, or when Ume6 is fused in frame to the Gal4 activation domain, Ume6 is converted from a repressor to an activator, resulting in the transcription of meiosis-specific genes and the formation of asci. IS - 5 JF - Molecular and cellular biology SN - 0270-7306 EP - 2526 TI - Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional represssor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1. VL - 16 SP - 2518 KW - ime1 KW - meiosis KW - meiosis_regulation KW - sporulation KW - ume6 AU - Rubin-Bejerano, I AU - Mandel, S AU - Robzyk, K AU - Kassir, Y PY - 1996/05// UR - http://view.ncbi.nlm.nih.gov/pubmed/8628320 ER -