Regulation of APC/C Activators in Mitosis and Meiosis Export

@article{citeulike:4066343, abstract = {The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and Cdh1/Fizzy-related activate the APC/C and confer substrate specificity through complex interactions with both the core APC/C and substrate proteins. The regulation of Cdc20 and Cdh1 is critical for proper APC/C activity and occurs in multiple ways: targeted protein degradation, phosphorylation, and direct binding of inhibitory proteins. During the specialized divisions of meiosis, the activity of the APC/C must be modified to achieve proper chromosome segregation. Recent studies show that one way in which APC/C activity is modified is through the use of meiosis-specific APC/C activators. Furthermore, regulation of the APC/C during meiosis is carried out by both mitotic regulators of the APC/C as well as meiosis-specific regulators. Here, we review the regulation of APC/C activators during mitosis and the role and regulation of the APC/C during female meiosis.}, author = {Pesin, Jillian A. and Terry}, citeulike-article-id = {4066343}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.cellbio.041408.115949}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.cellbio.041408.115949}, doi = {10.1146/annurev.cellbio.041408.115949}, journal = {Annual Review of Cell and Developmental Biology}, keywords = {apc, meiosis, mitosis}, number = {1}, pages = {475--499}, posted-at = {2009-03-04 15:59:43}, priority = {2}, title = {Regulation of APC/C Activators in Mitosis and Meiosis}, url = {http://dx.doi.org/10.1146/annurev.cellbio.041408.115949}, volume = {24}, year = {2008} }

TY - JOUR ID - citeulike:4066343 L3 - citeulike-article-id:4066343 N2 - The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and Cdh1/Fizzy-related activate the APC/C and confer substrate specificity through complex interactions with both the core APC/C and substrate proteins. The regulation of Cdc20 and Cdh1 is critical for proper APC/C activity and occurs in multiple ways: targeted protein degradation, phosphorylation, and direct binding of inhibitory proteins. During the specialized divisions of meiosis, the activity of the APC/C must be modified to achieve proper chromosome segregation. Recent studies show that one way in which APC/C activity is modified is through the use of meiosis-specific APC/C activators. Furthermore, regulation of the APC/C during meiosis is carried out by both mitotic regulators of the APC/C as well as meiosis-specific regulators. Here, we review the regulation of APC/C activators during mitosis and the role and regulation of the APC/C during female meiosis. IS - 1 JF - Annual Review of Cell and Developmental Biology EP - 499 TI - Regulation of APC/C Activators in Mitosis and Meiosis VL - 24 SP - 475 KW - apc KW - meiosis KW - mitosis AU - Pesin, Jillian AU - Terry PY - 2008/// UR - http://dx.doi.org/10.1146/annurev.cellbio.041408.115949 ER -