Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. Export

@article{citeulike:2766973, abstract = {We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the exception of 2, began in childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions that, although centered on the cortex or amygdala, extended into the underlying white matter for a short distance. Histologically, the variably infiltrative tumors were distinctively angiocentric with well-developed perivascular pseudorosettes in some cases. Longitudinal and/or circumferential orientations of perivascular cells were common also. The cells were uniform in their cytologic features from case to case and were bipolar in all but one case. A glial nature was inferred from immunoreactivity for GFAP, and ependymal differentiation was suggested by positivity for EMA in three cases and ultrastructural features in one. Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal.}, address = {Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Medical School, Houston, Texas, USA.}, author = {Wang, M. and Tihan, T. and Rojiani, A. M. and Bodhireddy, S. R. and Prayson, R. A. and Iacuone, J. J. and Alles, A. J. and Donahue, D. J. and Hessler, R. B. and Kim, J. H. and Haas, M. and Rosenblum, M. K. and Burger, P. C.}, citeulike-article-id = {2766973}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/16215459}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=16215459}, issn = {0022-3069}, journal = {Journal of neuropathology and experimental neurology}, keywords = {anet, angiocentric-neuroepithelial-tumor, neuro-oncologie}, month = {October}, number = {10}, pages = {875--881}, posted-at = {2008-05-07 17:41:07}, priority = {2}, title = {Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/16215459}, volume = {64}, year = {2005} }

TY - JOUR ID - citeulike:2766973 L3 - citeulike-article-id:2766973 N2 - We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the exception of 2, began in childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions that, although centered on the cortex or amygdala, extended into the underlying white matter for a short distance. Histologically, the variably infiltrative tumors were distinctively angiocentric with well-developed perivascular pseudorosettes in some cases. Longitudinal and/or circumferential orientations of perivascular cells were common also. The cells were uniform in their cytologic features from case to case and were bipolar in all but one case. A glial nature was inferred from immunoreactivity for GFAP, and ependymal differentiation was suggested by positivity for EMA in three cases and ultrastructural features in one. Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal. IS - 10 JF - Journal of neuropathology and experimental neurology SN - 0022-3069 AD - Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Medical School, Houston, Texas, USA. EP - 881 TI - Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. VL - 64 SP - 875 KW - anet KW - angiocentric-neuroepithelial-tumor KW - neuro-oncologie AU - Wang, M AU - Tihan, T AU - Rojiani, AM AU - Bodhireddy, SR AU - Prayson, RA AU - Iacuone, JJ AU - Alles, AJ AU - Donahue, DJ AU - Hessler, RB AU - Kim, JH AU - Haas, M AU - Rosenblum, MK AU - Burger, PC PY - 2005/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/16215459 ER -