Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights Export

@article{citeulike:1016800, abstract = {Most studies of protein networks operate on a high level of abstraction, neglecting structural and chemical aspects of each interaction. Here, we characterize interactions by using atomic-resolution information from three-dimensional protein structures. We find that some previously recognized relationships between network topology and genomic features (e.g., hubs tending to be essential proteins) are actually more reflective of a structural quantity, the number of distinct binding interfaces. Subdividing hubs with respect to this quantity provides insight into their evolutionary rate and indicates that additional mechanisms of network growth are active in evolution (beyond effective preferential attachment through gene duplication). 10.1126/science.1136174}, address = {Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.}, author = {Kim, P. M. and Lu, L. J. and Xia, Y. and Gerstein, M. B.}, citeulike-article-id = {1016800}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1136174}, citeulike-linkout-1 = {http://www.sciencemag.org/content/314/5807/1938.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/314/5807/1938.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/314/5807/1938}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/17185604}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=17185604}, day = {22}, doi = {10.1126/science.1136174}, issn = {1095-9203}, journal = {Science}, month = {December}, number = {5807}, pages = {1938--1941}, posted-at = {2009-03-06 16:08:34}, priority = {2}, title = {Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights}, url = {http://dx.doi.org/10.1126/science.1136174}, volume = {314}, year = {2006} }

TY - JOUR ID - citeulike:1016800 L3 - citeulike-article-id:1016800 N2 - Most studies of protein networks operate on a high level of abstraction, neglecting structural and chemical aspects of each interaction. Here, we characterize interactions by using atomic-resolution information from three-dimensional protein structures. We find that some previously recognized relationships between network topology and genomic features (e.g., hubs tending to be essential proteins) are actually more reflective of a structural quantity, the number of distinct binding interfaces. Subdividing hubs with respect to this quantity provides insight into their evolutionary rate and indicates that additional mechanisms of network growth are active in evolution (beyond effective preferential attachment through gene duplication). 10.1126/science.1136174 IS - 5807 JF - Science SN - 1095-9203 AD - Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. EP - 1941 TI - Relating Three-Dimensional Structures to Protein Networks Provides Evolutionary Insights VL - 314 SP - 1938 AU - Kim, PM AU - Lu, LJ AU - Xia, Y AU - Gerstein, MB PY - 2006/12/22/ UR - http://dx.doi.org/10.1126/science.1136174 ER -