Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

Lung cancer is an aggressive and heterogeneous disease.1,2 Advances in surgical, radiotherapeutic, and chemotherapeutic approaches have been made, but the long-term survival rate remains low.3 After the Surgeon General's 1964 report on smoking and health, mortality from lung cancer among men peaked and then fell; among women, the peak occurred later and a slight decline has occurred more recently.4 Even though the rate of heavy smoking continues to decline in the United States,5 94 million current or former smokers remain at elevated risk for the disease,6 and lung cancer remains the leading cause of death from cancer in this . . .