Functional brain correlates of response time variability in children Export

@article{citeulike:1142264, abstract = {doi:10.1016/j.neuropsychologia.2007.01.013 During tasks requiring response inhibition, intra0individual response time variability, a measure of motor response preparation, has been found to correlate with errors of commission, such that individuals with higher variability show increased commission erros. This study used fMRI to examine neural correlates of response variability in 30 typically developing children, ages 8 to 12, using a simplified Go/No-Go task with minimal cognitive demands. Lower variability was associated with Go activation in the anterior cerebellum and with No-Go activation in the rostral SMA, the postcentral gyris, the anterior cerebellum and the inferior parietal lobule. For both Go and NoGO events, higher variability was associated with activation in prefrontal cortex and the caudate. The findings have implications for neuropsychiatric disorders such as ADHD and suggest that during response inhibition, children with more consistent performance are able to rely on premotor regions, such as the SMA, importnat for response selection; those with less consistent performance instead recruit prefrontal circuits involved in more complex aspects of behavioral control.}, author = {Simmonds, Daniel J. and Fotedar, Sunaina G. and Suskauer, Stacy J. and Pekar, James J. and Denckla, Martha B. and Mostofsky, Stewart H.}, citeulike-article-id = {1142264}, citeulike-linkout-0 = {http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0D-4MW324F-1-1&_cdi=4860&_user=918210&_orig=search&_coverDate=01%2F21%2F2007&_sk=999999999&view=c&wchp=dGLbVzb-zSkWW&md5=cf5274c780135b42cb7398fb2b679baa&ie=/sdarticle.pdf}, comment = {see summary here: http://scienceblogs.com/developingintelligence/2007/02/does\_response\_inhibition\_reall.php}, journal = {Neuropsychologia}, keywords = {afc, dlpfc, go\_nogo, response\_inhibition, rt\_variability}, posted-at = {2007-03-05 20:55:12}, priority = {2}, title = {Functional brain correlates of response time variability in children}, url = {http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0D-4MW324F-1-1&_cdi=4860&_user=918210&_orig=search&_coverDate=01%2F21%2F2007&_sk=999999999&view=c&wchp=dGLbVzb-zSkWW&md5=cf5274c780135b42cb7398fb2b679baa&ie=/sdarticle.pdf}, year = {2007} }

TY - JOUR ID - citeulike:1142264 L3 - citeulike-article-id:1142264 N2 - doi:10.1016/j.neuropsychologia.2007.01.013 During tasks requiring response inhibition, intra0individual response time variability, a measure of motor response preparation, has been found to correlate with errors of commission, such that individuals with higher variability show increased commission erros. This study used fMRI to examine neural correlates of response variability in 30 typically developing children, ages 8 to 12, using a simplified Go/No-Go task with minimal cognitive demands. Lower variability was associated with Go activation in the anterior cerebellum and with No-Go activation in the rostral SMA, the postcentral gyris, the anterior cerebellum and the inferior parietal lobule. For both Go and NoGO events, higher variability was associated with activation in prefrontal cortex and the caudate. The findings have implications for neuropsychiatric disorders such as ADHD and suggest that during response inhibition, children with more consistent performance are able to rely on premotor regions, such as the SMA, importnat for response selection; those with less consistent performance instead recruit prefrontal circuits involved in more complex aspects of behavioral control. JF - Neuropsychologia TI - Functional brain correlates of response time variability in children KW - afc KW - dlpfc KW - go_nogo KW - response_inhibition KW - rt_variability N1 - see summary here: http://scienceblogs.com/developingintelligence/2007/02/does_response_inhibition_reall.php AU - Simmonds, Daniel AU - Fotedar, Sunaina AU - Suskauer, Stacy AU - Pekar, James AU - Denckla, Martha AU - Mostofsky, Stewart PY - 2007/// UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0D-4MW324F-1-1&_cdi=4860&_user=918210&_orig=search&_coverDate=01%2F21%2F2007&_sk=999999999&view=c&wchp=dGLbVzb-zSkWW&md5=cf5274c780135b42cb7398fb2b679baa&ie=/sdarticle.pdf ER -