When 'go' and 'nogo' are equally frequent: ERP components and cortical tomography. Export

@article{citeulike:1142290, abstract = {In human electrophysiology, a considerable corpus of studies using event-related potentials have investigated inhibitory processes by employing the 'go-nogo' paradigm, which requires responding to one type of event while withholding the response to another type of event. Two event-related potential waveform features (N2 and P3) have been associated with larger amplitude in nogo trials than in go trials. Traditionally, these differences were thought to reflect response inhibition. Recently, the source localization of N2 to the anterior cingulate cortex, as well as the colocalization of N2 with error-related negativity, has been interpreted in terms of conflict monitoring. In order to isolate the contribution of inhibitory processes, we matched the frequency of the go and nogo events, thus minimizing differences in response conflict between event types. A data-driven analytical procedure contrasted go with nogo events across the entire event-related potential segment and found that N2 reliably differentiated between the two conditions while P3 did not. Tomographical analyses of the N2 difference observed in conditions of equal go and nogo trial frequency localized N2 to the right ventral and dorsolateral prefrontal cortex. Because a growing body of evidence implicates these brain regions in inhibitory processes, we conclude that N2 does, at least in part, reflect inhibition.}, address = {School of Psychology, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, England. A.Lavric@exeter.ac.uk}, author = {Lavric, A. and Pizzagalli, D. A. and Forstmeier, S.}, citeulike-article-id = {1142290}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1460-9568.2004.03683.x}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15525290}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15525290}, comment = {see summary here: http://scienceblogs.com/developingintelligence/2007/02/noveltyrelated\_processing\_in\_t.php}, doi = {10.1111/j.1460-9568.2004.03683.x}, issn = {0953-816X}, journal = {Eur J Neurosci}, keywords = {dlpfc, equal\_frequency, go\_nogo, loreta, monitoring, response\_inhibition, rt\_variability, vlpfc}, month = {November}, number = {9}, pages = {2483--2488}, posted-at = {2007-03-05 21:10:26}, priority = {2}, title = {When 'go' and 'nogo' are equally frequent: ERP components and cortical tomography.}, url = {http://dx.doi.org/10.1111/j.1460-9568.2004.03683.x}, volume = {20}, year = {2004} }

TY - JOUR ID - citeulike:1142290 L3 - citeulike-article-id:1142290 N2 - In human electrophysiology, a considerable corpus of studies using event-related potentials have investigated inhibitory processes by employing the 'go-nogo' paradigm, which requires responding to one type of event while withholding the response to another type of event. Two event-related potential waveform features (N2 and P3) have been associated with larger amplitude in nogo trials than in go trials. Traditionally, these differences were thought to reflect response inhibition. Recently, the source localization of N2 to the anterior cingulate cortex, as well as the colocalization of N2 with error-related negativity, has been interpreted in terms of conflict monitoring. In order to isolate the contribution of inhibitory processes, we matched the frequency of the go and nogo events, thus minimizing differences in response conflict between event types. A data-driven analytical procedure contrasted go with nogo events across the entire event-related potential segment and found that N2 reliably differentiated between the two conditions while P3 did not. Tomographical analyses of the N2 difference observed in conditions of equal go and nogo trial frequency localized N2 to the right ventral and dorsolateral prefrontal cortex. Because a growing body of evidence implicates these brain regions in inhibitory processes, we conclude that N2 does, at least in part, reflect inhibition. IS - 9 JF - Eur J Neurosci SN - 0953-816X AD - School of Psychology, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, England. A.Lavric@exeter.ac.uk EP - 2488 TI - When 'go' and 'nogo' are equally frequent: ERP components and cortical tomography. VL - 20 SP - 2483 KW - dlpfc KW - equal_frequency KW - go_nogo KW - loreta KW - monitoring KW - response_inhibition KW - rt_variability KW - vlpfc N1 - see summary here: http://scienceblogs.com/developingintelligence/2007/02/noveltyrelated_processing_in_t.php AU - Lavric, A AU - Pizzagalli, DA AU - Forstmeier, S PY - 2004/11// UR - http://dx.doi.org/10.1111/j.1460-9568.2004.03683.x ER -