Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing Export

@article{citeulike:1142313, abstract = {Execution of higher cortical functions requires inhibitory control to restrain habitual responses and meet changing task demands. We used functional magnetic resonance imaging to show the neural correlates of response inhibition during a stop-signal task. The task has a frequent "go" stimulus to set up a pre-potent response tendency and a less frequent "stop" signal for subjects to withhold their response. We contrasted brain activation between successful and failed inhibition for individual subjects and compared groups of subjects with short and long stop-signal reaction times. The two groups of subjects did not differ in their inhibition failure rates or the extent of signal monitoring, error monitoring, or task-associated frustration ratings. The results showed that short stop-signal reaction time or more efficient response inhibition was associated with greater activation in the superior medial and precentral frontal cortices. Moreover, activation of these inhibitory motor areas correlated negatively with stop-signal reaction time. These brain regions may represent the neural substrata of response inhibition independent of other cognitive and affective functions. 10.1523/JNEUROSCI.3741-05.2006}, author = {Ray and Huang, Cong and Constable, Todd R. and Sinha, Rajita}, citeulike-article-id = {1142313}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.3741}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/26/1/186}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16399686}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16399686}, comment = {Li et al. state that "by contrasting successful and failed inhibition, one might simply be isolating activations related to such signal monitoring process." They then try to address this monitoring confound by contrasting groups with long and short SSRTs. Although I think this contrast still contains differences in monitoring efficacy, apparently it's enough to get rid of the right PFC activations: they show *no significant differences* in right PFC activations in that contrast. They gingerly conclude that "Although signal monitoring can explain the activation of the IFC in these previous neuroimaging studies and the work of Aron et al. (2003) found that patients with right inferior frontal lesions were impaired in stop-signal inhibitions, a general attention mechanism could also be at play in causing inhibitory control deficits resulting from lesions in the IFC." }, day = {4}, doi = {10.1523/JNEUROSCI.3741}, journal = {J. Neurosci.}, keywords = {1crt, 25\_percent\_stop\_trials, failed\_vs\_successful\_inhibition, ifg, monitoring, response\_inhibition, ssrt, vlpfc}, month = {January}, number = {1}, pages = {186--192}, posted-at = {2007-03-05 21:29:32}, priority = {2}, title = {Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing}, url = {http://dx.doi.org/10.1523/JNEUROSCI.3741}, volume = {26}, year = {2006} }

TY - JOUR ID - citeulike:1142313 L3 - citeulike-article-id:1142313 N2 - Execution of higher cortical functions requires inhibitory control to restrain habitual responses and meet changing task demands. We used functional magnetic resonance imaging to show the neural correlates of response inhibition during a stop-signal task. The task has a frequent "go" stimulus to set up a pre-potent response tendency and a less frequent "stop" signal for subjects to withhold their response. We contrasted brain activation between successful and failed inhibition for individual subjects and compared groups of subjects with short and long stop-signal reaction times. The two groups of subjects did not differ in their inhibition failure rates or the extent of signal monitoring, error monitoring, or task-associated frustration ratings. The results showed that short stop-signal reaction time or more efficient response inhibition was associated with greater activation in the superior medial and precentral frontal cortices. Moreover, activation of these inhibitory motor areas correlated negatively with stop-signal reaction time. These brain regions may represent the neural substrata of response inhibition independent of other cognitive and affective functions. 10.1523/JNEUROSCI.3741-05.2006 IS - 1 JF - J. Neurosci. EP - 192 TI - Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing VL - 26 SP - 186 KW - 1crt KW - 25_percent_stop_trials KW - failed_vs_successful_inhibition KW - ifg KW - monitoring KW - response_inhibition KW - ssrt KW - vlpfc N1 - Li et al. state that "by contrasting successful and failed inhibition, one might simply be isolating activations related to such signal monitoring process." They then try to address this monitoring confound by contrasting groups with long and short SSRTs. Although I think this contrast still contains differences in monitoring efficacy, apparently it's enough to get rid of the right PFC activations: they show *no significant differences* in right PFC activations in that contrast. They gingerly conclude that "Although signal monitoring can explain the activation of the IFC in these previous neuroimaging studies and the work of Aron et al. (2003) found that patients with right inferior frontal lesions were impaired in stop-signal inhibitions, a general attention mechanism could also be at play in causing inhibitory control deficits resulting from lesions in the IFC." AU - Ray AU - Huang, Cong AU - Constable, Todd AU - Sinha, Rajita PY - 2006/01/04/ UR - http://dx.doi.org/10.1523/JNEUROSCI.3741 ER -