Inhibition in children with attention-deficit/hyperactivity disorder: a psychophysiological study of the stop task. Export

@article{citeulike:1144198, abstract = {BACKGROUND: The purpose of the study was to investigate and identify abnormal brain activity, as revealed by event-related potentials (ERPs) concurring with deficient inhibitory control in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Performance and ERPs from 16 children with ADHD and 16 control subjects were compared in the stop-signal paradigm. RESULTS: The ADHD children showed a lower inhibition percentage and their (estimated) response time to the stop signal was disproportionally longer compared to the slowing of reaction times to primary-task stimuli. In normal control subjects, fronto-central positivity (100-400 msec) after the onset of the stop-signal was larger in case of successful inhibition, relative to failed inhibition; this was less so in ADHD children. A late positive wave (500-700 msec), maximal at Oz on failed inhibition trials, and possibly related to error-detection, was smaller in ADHD children. CONCLUSIONS: These results point to abnormalities in brain processes involved in motor inhibition and error-detection in ADHD children.}, address = {Faculty of Pharmacy, Department of Psychopharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.}, author = {Overtoom, C. C. and Kenemans, J. L. and Verbaten, M. N. and Kemner, C. and van der Molen, M. W. and van Engeland, H. and Buitelaar, J. K. and Koelega, H. S.}, citeulike-article-id = {1144198}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11955467}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11955467}, day = {15}, issn = {0006-3223}, journal = {Biol Psychiatry}, keywords = {2crt, 40\_percent\_stop\_trials, adhd, axcpt, deficit, disorder, failed\_vs\_successful\_inhibition, monitoring, p3, response\_inhibition, rt\_variability, ssrt}, month = {April}, number = {8}, pages = {668--676}, posted-at = {2007-03-06 17:06:57}, priority = {2}, title = {Inhibition in children with attention-deficit/hyperactivity disorder: a psychophysiological study of the stop task.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11955467}, volume = {51}, year = {2002} }

TY - JOUR ID - citeulike:1144198 L3 - citeulike-article-id:1144198 N2 - BACKGROUND: The purpose of the study was to investigate and identify abnormal brain activity, as revealed by event-related potentials (ERPs) concurring with deficient inhibitory control in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Performance and ERPs from 16 children with ADHD and 16 control subjects were compared in the stop-signal paradigm. RESULTS: The ADHD children showed a lower inhibition percentage and their (estimated) response time to the stop signal was disproportionally longer compared to the slowing of reaction times to primary-task stimuli. In normal control subjects, fronto-central positivity (100-400 msec) after the onset of the stop-signal was larger in case of successful inhibition, relative to failed inhibition; this was less so in ADHD children. A late positive wave (500-700 msec), maximal at Oz on failed inhibition trials, and possibly related to error-detection, was smaller in ADHD children. CONCLUSIONS: These results point to abnormalities in brain processes involved in motor inhibition and error-detection in ADHD children. IS - 8 JF - Biol Psychiatry SN - 0006-3223 AD - Faculty of Pharmacy, Department of Psychopharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands. EP - 676 TI - Inhibition in children with attention-deficit/hyperactivity disorder: a psychophysiological study of the stop task. VL - 51 SP - 668 KW - 2crt KW - 40_percent_stop_trials KW - adhd KW - axcpt KW - deficit KW - disorder KW - failed_vs_successful_inhibition KW - monitoring KW - p3 KW - response_inhibition KW - rt_variability KW - ssrt AU - Overtoom, CC AU - Kenemans, JL AU - Verbaten, MN AU - Kemner, C AU - van der Molen, MW AU - van Engeland, H AU - Buitelaar, JK AU - Koelega, HS PY - 2002/04/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11955467 ER -