Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans Export

@article{citeulike:528362, abstract = {Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior (response inhibition) and to learn from complex feedback (probabilistic learning), play critical roles in activities of daily life. To what extent do different neurochemical systems modulate these two cognitive functions? Here, using stop-signal and probabilistic learning tasks, we show a double dissociation for the involvement of noradrenaline and serotonin in human cognition. In healthy volunteers, inhibition of central noradrenaline reuptake improved response inhibition but had no effect on probabilistic learning, whereas inhibition of central serotonin reuptake impaired probabilistic learning with no effect on response inhibition.}, author = {Chamberlain, Samuel R. and Muller, Ulrich and Blackwell, Andrew D. and Clark, Luke and Robbins, Trevor W. and Sahakian, Barbara J.}, citeulike-article-id = {528362}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1121218}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/311/5762/861}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16469930}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16469930}, comment = {Atomoxetine enhances performance on SSRT}, day = {10}, doi = {10.1126/science.1121218}, journal = {Science}, keywords = {2crt, atomoxetine, deficit, drugs, na, ofc, ssrt}, month = {February}, number = {5762}, pages = {861--863}, posted-at = {2007-03-06 16:02:50}, priority = {2}, title = {Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans}, url = {http://dx.doi.org/10.1126/science.1121218}, volume = {311}, year = {2006} }

TY - JOUR ID - citeulike:528362 L3 - citeulike-article-id:528362 N2 - Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior (response inhibition) and to learn from complex feedback (probabilistic learning), play critical roles in activities of daily life. To what extent do different neurochemical systems modulate these two cognitive functions? Here, using stop-signal and probabilistic learning tasks, we show a double dissociation for the involvement of noradrenaline and serotonin in human cognition. In healthy volunteers, inhibition of central noradrenaline reuptake improved response inhibition but had no effect on probabilistic learning, whereas inhibition of central serotonin reuptake impaired probabilistic learning with no effect on response inhibition. IS - 5762 JF - Science EP - 863 TI - Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans VL - 311 SP - 861 KW - 2crt KW - atomoxetine KW - deficit KW - drugs KW - na KW - ofc KW - ssrt N1 - Atomoxetine enhances performance on SSRT AU - Chamberlain, Samuel AU - Muller, Ulrich AU - Blackwell, Andrew AU - Clark, Luke AU - Robbins, Trevor AU - Sahakian, Barbara PY - 2006/02/10/ UR - http://dx.doi.org/10.1126/science.1121218 ER -