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This chapter contains sections titled: * Introduction * Hepatocyte Transplantation: Rationale and Early Studies * Basic Requirements for Liver Regeneration * Molecular Regulation of Liver Mass * Animal Models to Augment Liver Repopulation by Transplanted Hepatocytes * “Oval Cells” as Hepatocyte Progenitors * Transplantation of “Oval Cells” * Stem Cells: Their Origin and Properties * Stem Cells in the Adult Liver and the Hepatic Stem Cell Niche * Hepatic Stem Cells in the Fetal Liver * Liver Repopulation by Fetal Liver Stem/Progenitor Cells * Liver Repopulation by Extrahepatic and Embryonic Stem Cells * Induced Pluripotent Stem Cells (IPS) * Other Roles for BM Cells in Liver Regeneration * Human “Oval Cells” and Stem Cells * Clinical Trials of Hepatocyte Transplantation * Treatment of Fulminant Hepatic Failure * Xenorepopulation Models * Future Horizons * Acknowledgments * References
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