Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands Export

@article{323, abstract = {OBJECTIVE: To study the incidence, signs and symptoms, diagnostic tests, risk factors, therapy, and complications of pediatric venous thromboembolism (VTE) in The Netherlands. METHODS: A prospective 2-year registry of VTE in children aged < or = 18 years. RESULTS: Ninety-nine patients were registered. The annual incidence of VTE was 0.14/10,000 children, 35\% of whom were symptom free. Almost half of the patients were newborns. Neonatal VTE was almost exclusively catheter related, located in the upper venous system, and asymptomatic. In older children VTE was catheter related in approximately one third and more often was located in the lower venous system. In 85\% of all patients, thrombosis developed while the patient was in the hospital. Diagnosis was usually made by ultrasonography. In 98\% of all patients, at least 1 risk factor was present. Congenital prothrombotic disorders were more often present in older children (21\%) than in neonates (6\%). A variety of treatment modalities were used. Morbidity consisted of bleeding (7\%) and recurrent thrombosis (7\%). Two children died as result of VTE. CONCLUSION: VTE is mostly diagnosed in hospitalized children, especially sick newborns with central venous catheters and older children with a combination of risk factors. Primary prevention, optimal treatment, and long-term outcome of pediatric symptomatic and asymptomatic VTE need to be studied.}, address = {Department of Pediatrics, Emma Children's Hospital AMC, Amsterdam, The Netherlands.}, author = {van Ommen, C. H. and Heijboer, H. and Buller, H. R. and Hirasing, R. A. and Heijmans, H. S. and Peters, M.}, citeulike-article-id = {2863082}, comment = {LR: 20041117; PUBM: Print; JID: 0375410; ppublish}, issn = {0022-3476}, journal = {The Journal of pediatrics}, keywords = {complication, epidemiology, risk-factor, thromboembolism}, number = {5}, pages = {676--681}, posted-at = {2008-06-05 00:53:21}, priority = {2}, title = {Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands}, volume = {139} }

TY - JOUR ID - 323 L3 - citeulike-article-id:2863082 N2 - OBJECTIVE: To study the incidence, signs and symptoms, diagnostic tests, risk factors, therapy, and complications of pediatric venous thromboembolism (VTE) in The Netherlands. METHODS: A prospective 2-year registry of VTE in children aged < or = 18 years. RESULTS: Ninety-nine patients were registered. The annual incidence of VTE was 0.14/10,000 children, 35% of whom were symptom free. Almost half of the patients were newborns. Neonatal VTE was almost exclusively catheter related, located in the upper venous system, and asymptomatic. In older children VTE was catheter related in approximately one third and more often was located in the lower venous system. In 85% of all patients, thrombosis developed while the patient was in the hospital. Diagnosis was usually made by ultrasonography. In 98% of all patients, at least 1 risk factor was present. Congenital prothrombotic disorders were more often present in older children (21%) than in neonates (6%). A variety of treatment modalities were used. Morbidity consisted of bleeding (7%) and recurrent thrombosis (7%). Two children died as result of VTE. CONCLUSION: VTE is mostly diagnosed in hospitalized children, especially sick newborns with central venous catheters and older children with a combination of risk factors. Primary prevention, optimal treatment, and long-term outcome of pediatric symptomatic and asymptomatic VTE need to be studied. IS - 5 JF - The Journal of pediatrics SN - 0022-3476 AD - Department of Pediatrics, Emma Children's Hospital AMC, Amsterdam, The Netherlands. EP - 681 TI - Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands VL - 139 SP - 676 KW - complication KW - epidemiology KW - risk-factor KW - thromboembolism N1 - LR: 20041117; PUBM: Print; JID: 0375410; ppublish AU - van Ommen, CH AU - Heijboer, H AU - Buller, HR AU - Hirasing, RA AU - Heijmans, HS AU - Peters, M ER -